{
  "patent_number": "US 4681893",
  "country": "US",
  "title": "The Chemical Formula for Atorvastatin, the Active Ingredient in Lipitor",
  "original_title": "Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis",
  "summary": "This patent describes the chemical structure of a class of molecules designed to block the enzyme responsible for cholesterol production in the human body.",
  "what_it_does": "The patent claims a specific chemical structure—a pyrrole-based compound—that acts as an inhibitor of the enzyme HMG-CoA reductase. By blocking this enzyme, the compound prevents the liver from synthesizing cholesterol. The structure includes a lactone ring, which can open into a hydroxy acid form that is biologically active in the body. Claim 5 specifically identifies the chemical structure that would later become known as Atorvastatin.",
  "what_it_does_not_cover": [
    "Does not cover naturally occurring cholesterol-lowering compounds found in plants or fungi.",
    "Does not cover other classes of cholesterol-lowering drugs like fibrates or bile acid sequestrants.",
    "Does not cover the specific manufacturing process or industrial synthesis route for the compound.",
    "Does not cover the use of these compounds for treating conditions unrelated to cholesterol biosynthesis."
  ],
  "filed": "1986-05-30",
  "granted": "1987-07-21",
  "expires": null,
  "status": "active",
  "holder": "Warner Lambert Co LLC",
  "holder_url": "https://patentbrief.org/company/warner-lambert-co-llc",
  "inventors": [
    {
      "name": "Bruce D. Roth",
      "url": "https://patentbrief.org/inventor/bruce-d-roth"
    }
  ],
  "times_cited": 340,
  "tags": [
    "pharmaceutical"
  ],
  "abstract": "Certain trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-ones and the corresponding ring-opened acids derived therefrom which are potent inhibitors of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG CoA reductase and are thus useful hypolipidemic or hypocholesterolemic agents. Pharmaceutical compositions containing such compounds, and a method of inhibiting the biosynthesis of cholesterol employing such pharmaceutical compositions are also disclosed.",
  "url": "https://patentbrief.org/patent/us/4681893/prozac-fluoxetine",
  "markdown_url": "https://patentbrief.org/patent/us/4681893/prozac-fluoxetine/md",
  "google_patents_url": "https://patents.google.com/patent/US4681893",
  "relatedPatents": []
}