{
  "patent_number": "US 4522811",
  "country": "US",
  "title": "Boosting Anti-Infective Activity with Muramyldipeptides and Liposomes",
  "original_title": "Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides",
  "summary": "This patent describes a method to make anti-infective drugs called muramyldipeptides work better by injecting them separately but close in time with tiny fat bubbles called liposomes into an animal.",
  "what_it_does": "The patent details a method to improve how well muramyldipeptide (MDP) compounds fight infections. This involves giving an animal two separate intravenous injections: first, an unencapsulated MDP compound, and second, liposomes. The key is that these two injections must happen within three hours of each other, as stated in claim 1. This serial injection approach enhances the MDP compound's ability to combat infections. For example, if a lab animal has a bacterial infection, this method could make the MDP treatment more effective than giving the MDP alone.",
  "what_it_does_not_cover": [
    "Does not cover injecting the muramyldipeptide (MDP) compound directly inside the liposomes; it specifies 'unencapsulated MDP compound' in claim 1.",
    "Does not cover administering the MDP compound and liposomes more than three hours apart, as claim 1 requires them to be 'within three hours of each other'.",
    "Does not cover methods of delivery other than 'serial intravenous injection' (e.g., oral administration or intramuscular shots).",
    "Does not cover using MDP compounds or liposomes alone; the method requires both components to be serially injected.",
    "Does not cover applications outside of 'an animal in need thereof', meaning it's not for cell cultures or inanimate objects."
  ],
  "filed": "1982-07-08",
  "granted": "1985-06-11",
  "expires": null,
  "status": "active",
  "holder": "Syntex USA LLC",
  "holder_url": "https://patentbrief.org/company/syntex-usa-llc",
  "inventors": [
    {
      "name": "Elizabeth B. Fraser-Smith",
      "url": "https://patentbrief.org/inventor/elizabeth-b-fraser-smith"
    },
    {
      "name": "Thomas R. Matthews",
      "url": "https://patentbrief.org/inventor/thomas-r-matthews"
    },
    {
      "name": "Deborah A. Eppstein",
      "url": "https://patentbrief.org/inventor/deborah-a-eppstein"
    }
  ],
  "times_cited": 2340,
  "tags": [
    "biotech",
    "pharmaceutical",
    "drug_delivery",
    "immunology"
  ],
  "abstract": "Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides.",
  "url": "https://patentbrief.org/patent/us/4522811/human-growth-hormone-protropin",
  "markdown_url": "https://patentbrief.org/patent/us/4522811/human-growth-hormone-protropin/md",
  "google_patents_url": "https://patents.google.com/patent/US4522811",
  "relatedPatents": []
}