{
  "patent_number": "US 20250235403",
  "country": "US",
  "title": "Tiny Bubbles for Delivering Medicine",
  "original_title": "Compositions and methods of the delivery of active agents including nucleic acids",
  "summary": "This patent describes tiny, bubble-like structures made of fats that can carry medicine, like genetic material, and release it effectively inside the body by changing their structure in slightly acidic environments.",
  "what_it_does": "This patent is about special tiny bubbles, called nanoemulsions, designed to carry active substances, such as nucleic acids (like mRNA or DNA), into the body. These nanoemulsions are made of specific types of fats: ionizable lipids that can change their charge, neutral lipids for structure, and PEGylated lipids to help them last longer. A key feature is that these compositions are buffered to be slightly acidic, specifically between a pH of 5.0 and 6.5. This acidic environment helps the nanoemulsion release its cargo more efficiently once it reaches its target, improving how well the medicine works. For example, a nanoemulsion containing mRNA for a vaccine could be designed to release the mRNA more effectively in the slightly acidic environment found within certain cellular compartments.",
  "what_it_does_not_cover": [
    "Nanoemulsions that are not buffered to a pH between 5.0 and 6.5.",
    "Compositions that do not contain ionizable lipids, neutral lipids, and PEGylated lipids.",
    "Delivery systems that do not encapsulate an active agent.",
    "Nanoemulsions that are buffered to a neutral or basic pH (e.g., pH 7 or higher).",
    "Delivery systems that do not include fusogenic oils, if the specific claims omitting them are considered."
  ],
  "filed": "2022-10-24",
  "granted": null,
  "expires": "2042-10-24",
  "status": "active",
  "holder": "Ohio State Innovation Foundation",
  "holder_url": "https://patentbrief.org/company/ohio-state-innovation-foundation",
  "inventors": [
    {
      "name": "Zhongkun Zhang",
      "url": "https://patentbrief.org/inventor/zhongkun-zhang"
    },
    {
      "name": "Chun-Tien KUO",
      "url": "https://patentbrief.org/inventor/chun-tien-kuo"
    },
    {
      "name": "Robert J. Lee",
      "url": "https://patentbrief.org/inventor/robert-j-lee"
    }
  ],
  "times_cited": 0,
  "tags": [
    "pharmaceutical",
    "biotech",
    "materials",
    "semiconductors"
  ],
  "abstract": "Disclosed herein are pH-sensitive nanoemulsions as well as methods of using thereof. These pH-sensitive nanoemulsions can comprise a lipid particle encapsulating an active agent. The lipid particle can comprise one or more ionizable lipids; one or more neutral lipids; one or more PEGylated lipids; and optionally one or more fusogenic oils. In some embodiments, these compositions can be buffered at an acidic pH (e.g., a pH of less than 6.5, such as a pH of from 4 to 6.5, or a pH of from 5.0 to 6.5). By buffering at an acidic pH, the delivery efficiency of the compositions can be enhanced as compared to otherwise identical compositions buffered at a pH of 7 or more.",
  "url": "https://patentbrief.org/patent/us/20250235403/compositions-and-methods-of-the-delivery-of-active-agents-including-nucleic-acid",
  "markdown_url": "https://patentbrief.org/patent/us/20250235403/compositions-and-methods-of-the-delivery-of-active-agents-including-nucleic-acid/md",
  "google_patents_url": "https://patents.google.com/patent/US20250235403",
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}