{
  "patent_number": "US 20250171803",
  "country": "US",
  "title": "Targeting Cancer with CAR T Cells Using Small Molecule 'Flags'",
  "original_title": "Methods and compositions for car t cell therapy",
  "summary": "This patent describes a method to treat cancer by giving a patient special immune cells (CAR T cells) that are trained to find a specific 'flag' molecule, and then also giving them a drug molecule attached to that same 'flag' in varying amounts or forms.",
  "what_it_does": "This patent details a method for treating cancer by combining CAR T cell therapy with targeted drug delivery. First, a patient receives CAR T cells, which are engineered immune cells designed to recognize a specific 'targeting moiety' (a molecular tag). Then, the patient receives a compound that consists of a 'small molecule ligand' (a drug-like molecule) linked to that same 'targeting moiety' by a 'linker'. The key innovation involves administering this compound in either different doses (Claim 1) or as different versions of the compound (different 'conjugates') (Claims 2 and 3). For example, a patient might receive CAR T cells that recognize a folate-based targeting moiety, and then receive different doses of a folate-linked small molecule drug to direct the CAR T cells to cancer cells.",
  "what_it_does_not_cover": [
    "CAR T cell therapies that target natural antigens on cancer cells without the use of an externally administered small molecule conjugate.",
    "Small molecule drug delivery systems that do not involve CAR T cells specifically directed to the small molecule's targeting moiety.",
    "Administering the small molecule ligand linked to a targeting moiety in a single, unchanging dose, or as only one type of conjugate.",
    "CAR T cells that are not specifically engineered to recognize the same targeting moiety as the administered small molecule conjugate.",
    "Methods where the small molecule ligand is not linked to a targeting moiety by a linker, as described in the claims."
  ],
  "filed": "2024-10-14",
  "granted": null,
  "expires": "2044-10-14",
  "status": "active",
  "holder": "Purdue Research Foundation",
  "holder_url": "https://patentbrief.org/company/purdue-research-foundation",
  "inventors": [
    {
      "name": "Philip Stewart Low",
      "url": "https://patentbrief.org/inventor/philip-stewart-low"
    },
    {
      "name": "Yong Gu Lee",
      "url": "https://patentbrief.org/inventor/yong-gu-lee"
    },
    {
      "name": "Haiyan CHU",
      "url": "https://patentbrief.org/inventor/haiyan-chu"
    }
  ],
  "times_cited": 0,
  "tags": [
    "biotech",
    "pharmaceutical",
    "gene_editing",
    "oncology"
  ],
  "abstract": "The present disclosure relates to methods of treating a patient with a cancer by administering to the patient a composition comprising CAR T cells and a small molecule linked to a targeting moiety by a linker. The disclosure also relates to compositions for use in such methods.",
  "url": "https://patentbrief.org/patent/us/20250171803/methods-and-compositions-for-car-t-cell-therapy",
  "markdown_url": "https://patentbrief.org/patent/us/20250171803/methods-and-compositions-for-car-t-cell-therapy/md",
  "google_patents_url": "https://patents.google.com/patent/US20250171803",
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}