# Better Lab Tests with Engineered Humanized Antibodies > This patent describes a special lab test ingredient, a 'humanized antibody,' designed to make medical and research tests more accurate by preventing false alarms. - **Patent:** US 20250102496 - **Original title:** Reagent containing humanized antibody - **Owner:** Denka Co - **Status:** Active - **Times cited:** 0 - **Field:** biotech, pharmaceutical, diagnostics, research_tools ## What it does This patent describes an immunoassay reagent, which is a key ingredient for laboratory tests. This reagent contains a 'humanized antibody' that targets a specific substance (Claim 1). The special feature of this antibody is its ability to 'inhibit a non-specific reaction' (Claim 2), meaning it only binds to its intended target and avoids reacting with other similar substances that could cause false results. The patent also covers a 'kit' that includes this reagent (Claim 7) and an 'immunoassay method' for using it (Claim 8). For example, a diagnostic test for a specific virus would use this humanized antibody to accurately detect only that virus, ignoring other harmless substances in a blood sample. ## What it does NOT cover - Immunoassay reagents that use antibodies which are not 'humanized' (e.g., purely animal-derived antibodies). - Humanized antibodies that do not specifically 'inhibit a non-specific reaction' (Claim 2). - Lab tests that do not involve antibodies, such as those that detect DNA or RNA directly. - Methods for inhibiting non-specific reactions that do not involve the use of a humanized antibody. - Immunoassay methods where the humanized antibody is not brought into contact with the target substance (Claim 8). ## The clever bit The novelty lies in specifically designing or selecting a 'humanized antibody' that is engineered to actively 'inhibit a non-specific reaction.' This targeted ability makes diagnostic and research tests more reliable by reducing false positives or negatives. ## Real-world examples 1. Diagnostic test kits for infectious diseases 2. Blood tests for specific disease biomarkers 3. Research assays for detecting proteins in biological samples 4. Tests for allergens or environmental toxins ## Why it matters Accurate diagnostic tests are vital for healthcare and scientific research. By reducing 'non-specific reactions,' this technology aims to prevent misleading results in medical tests, which can lead to better patient care and more reliable scientific discoveries. It helps ensure that when a test says something is present, it truly is, and when it says it's absent, it truly is. ## Frequently asked questions ### What does Better Lab Tests with Engineered Humanized Antibodies cover? This patent describes a special lab test ingredient, a 'humanized antibody,' designed to make medical and research tests more accurate by preventing false alarms. ### Who owns patent US 20250102496? This patent is owned by Denka Co. ### When does this patent expire? This patent is expected to expire on July 26, 2042, when the invention enters the public domain. ### What problem does this patent solve? Accurate diagnostic tests are vital for healthcare and scientific research. By reducing 'non-specific reactions,' this technology aims to prevent misleading results in medical tests, which can lead to better patient care and more reliable scientific discoveries. It helps ensure that when a test says something is present, it truly is, and when it says it's absent, it truly is. ### What does this patent NOT cover? Immunoassay reagents that use antibodies which are not 'humanized' (e.g., purely animal-derived antibodies). **Full plain-English explainer:** https://patentbrief.org/patent/us/20250102496/reagent-containing-humanized-antibody **Original patent:** https://patents.google.com/patent/US20250102496 --- _Source: PatentBrief — https://patentbrief.org. Patent facts are from public records; the plain-English explanation is PatentBrief's._ ## Related patents Semantically similar inventions in the PatentBrief corpus: - [How Scientists Create Human-Friendly Antibodies for Medicine](https://patentbrief.org/patent/us/5585089/remicade-infliximab) — This patent describes a method for modifying mouse antibodies so human immune systems accept them as their own, allowing them to be used as powerful, long-lasting medical treatments. - [How to Find Antibodies That Only Detect Bound Drug Targets](https://patentbrief.org/patent/us/12590172/complex-specific-antibodies-and-antibody-fragments-and-its-use) — This patent describes a method to create and use special antibodies that only detect when a therapeutic or diagnostic antibody is bound to its target, ignoring both the target and the unbound antibody. - [How Two Special Antibodies Find Substances in Body Fluids](https://patentbrief.org/patent/us/4376110/psa-test-for-prostate-cancer) — This patent describes a "sandwich" method using two highly specific, man-made antibodies to detect and measure tiny amounts of specific substances, like disease markers, in a fluid sample. - [How to Redesign Mouse Antibodies for Safe Use in Humans](https://patentbrief.org/patent/us/6054297/rituxan-chop-chemotherapy) — Genentech's 1995 patent on a systematic method for humanizing rodent antibodies by grafting their disease-targeting loops onto a human consensus framework while carefully swapping key structural support residues to maintain binding strength. - [Making Hybrid Antibodies from Different Animals](https://patentbrief.org/patent/us/4816567/recombinant-antibody-production-in-cho-cells) — This patent describes how to create new, engineered antibodies by combining parts of antibodies from two different animal species, then growing them in a lab.