{
  "patent_number": "US 20240165159",
  "country": "US",
  "title": "Targeting Cancer with CAR T Cells Using a Chemical Tag",
  "original_title": "Compositions and methods for car t cell therapy",
  "summary": "This patent describes a method to treat cancer by giving a patient special immune cells (CAR T cells) that recognize a chemical tag, which is attached to a small drug molecule, along with a separate folate compound.",
  "what_it_does": "The patent outlines a three-step method to treat cancer. First, a patient receives a compound where a small drug molecule is connected to a \"targeting moiety\" (like a chemical tag) by a \"linker\" (Claim 1(i)). Second, the patient gets CAR T cells, which are engineered immune cells designed to specifically recognize and bind to this \"targeting moiety\" (Claim 1(ii)). Third, a \"folate conjugate\" is administered, which is a folate molecule linked to other parts, but importantly, this conjugate *does not* have the targeting moiety that the CAR T cells recognize (Claim 1(iii)). For example, if the targeting moiety is FITC (Claim 3), the CAR T cells would have an anti-FITC antibody part (Claim 12) to find and attack cells marked by the FITC-tagged compound.",
  "what_it_does_not_cover": [
    "Does not cover methods where the initial compound (small molecule ligand + linker + targeting moiety) is an antibody or an antibody fragment (Claim 11).",
    "Does not cover CAR T cell therapies where the CAR T cells directly target cancer cells without an intermediate targeting moiety.",
    "Does not cover methods where the administered folate conjugate also contains the specific targeting moiety that the CAR T cells are designed to recognize (Claim 1(iii)).",
    "Does not cover methods that do not involve all three distinct administration steps: the compound, the CAR T cells, and the folate conjugate (Claim 1)."
  ],
  "filed": "2023-10-25",
  "granted": null,
  "expires": "2043-10-25",
  "status": "active",
  "holder": "Purdue Research Foundation",
  "holder_url": "https://patentbrief.org/company/purdue-research-foundation",
  "inventors": [
    {
      "name": "Christopher Paul Leamon",
      "url": "https://patentbrief.org/inventor/christopher-paul-leamon"
    },
    {
      "name": "II Leroy W. WHEELER",
      "url": "https://patentbrief.org/inventor/ii-leroy-w-wheeler"
    },
    {
      "name": "Philip Stewart Low",
      "url": "https://patentbrief.org/inventor/philip-stewart-low"
    },
    {
      "name": "Yingjuan J. LU",
      "url": "https://patentbrief.org/inventor/yingjuan-j-lu"
    },
    {
      "name": "Yong Gu Lee",
      "url": "https://patentbrief.org/inventor/yong-gu-lee"
    },
    {
      "name": "Haiyan CHU",
      "url": "https://patentbrief.org/inventor/haiyan-chu"
    }
  ],
  "times_cited": 1,
  "tags": [
    "biotech",
    "pharmaceutical",
    "gene_editing",
    "oncology"
  ],
  "abstract": "The present disclosure relates to methods of treating a patient with a cancer by administering to the patient a composition comprising CAR T cells and a small molecule linked to a targeting moiety by a linker. The disclosure also relates to compositions for use in such methods.",
  "url": "https://patentbrief.org/patent/us/20240165159/compositions-and-methods-for-car-t-cell-therapy",
  "markdown_url": "https://patentbrief.org/patent/us/20240165159/compositions-and-methods-for-car-t-cell-therapy/md",
  "google_patents_url": "https://patents.google.com/patent/US20240165159",
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}