{
  "patent_number": "US 20240082373",
  "country": "US",
  "title": "How Special Molecules Boost Cancer-Fighting CAR-T Cells",
  "original_title": "Compositions for chimeric antigen receptor t cell therapy and uses thereof",
  "summary": "This patent describes special molecules made of a CAR-T cell activator attached to a fat-like part, designed to make cancer-fighting CAR-T cells grow and work better inside a patient.",
  "what_it_does": "The patent describes a method (Claim 77) to make chimeric antigen receptor-T (CAR-T) cells more active and numerous in a patient. It does this by giving the patient an \"amphiphilic ligand conjugate.\" This conjugate has two main parts: a \"chimeric antigen receptor (CAR) ligand\" and a \"lipid\" (Claim 77). The CAR ligand is like a key that specifically binds to the CAR \"lock\" on the CAR-T cells, telling them to multiply. The lipid part (Claim 78) helps the conjugate insert into cell membranes, like those of antigen-presenting cells in lymph nodes (Claim 92), and can also bind to albumin in the body. This delivery system helps the CAR-T cells get the signal they need to fight cancer more effectively (Claim 97). For example, a patient with cancer could be given these conjugates, potentially along with their CAR-T cells (Claim 96), to enhance the CAR-T cells' ability to attack tumor cells (Claim 101).",
  "what_it_does_not_cover": [
    "Does not cover methods of activating CAR-T cells outside a living subject (e.g., in a lab dish), as Claim 77 specifies \"in a subject.\"",
    "Does not cover CAR-T cell activation using a ligand that is not operably linked to a lipid to form an amphiphilic conjugate (Claim 77).",
    "Does not cover CAR-T cell activation where the lipid part does not insert into a cell membrane or bind albumin under physiological conditions (Claim 78).",
    "Does not cover methods where the CAR ligand is not designed to bind to the CAR of the CAR-T cells (Claim 77).",
    "Does not cover CAR-T cell therapies that do not involve administering an amphiphilic ligand conjugate to the subject."
  ],
  "filed": "2023-06-21",
  "granted": null,
  "expires": "2043-06-21",
  "status": "active",
  "holder": "Massachusetts Institute of Technology",
  "holder_url": "https://patentbrief.org/company/massachusetts-institute-of-technology",
  "inventors": [
    {
      "name": "Leyuan Ma",
      "url": "https://patentbrief.org/inventor/leyuan-ma"
    },
    {
      "name": "Darrell J. Irvine",
      "url": "https://patentbrief.org/inventor/darrell-j-irvine"
    }
  ],
  "times_cited": 2,
  "tags": [
    "biotech",
    "pharmaceutical",
    "gene_editing",
    "immunology",
    "oncology"
  ],
  "abstract": "The disclosure features amphiphilic ligand conjugates comprising a chimeric antigen receptor (CAR)ligand and a lipid. The disclosure also features compositions and methods of using the same, for example, to stimulate proliferation of CAR expressing cells.",
  "url": "https://patentbrief.org/patent/us/20240082373/compositions-for-chimeric-antigen-receptor-t-cell-therapy-and-uses-thereof",
  "markdown_url": "https://patentbrief.org/patent/us/20240082373/compositions-for-chimeric-antigen-receptor-t-cell-therapy-and-uses-thereof/md",
  "google_patents_url": "https://patents.google.com/patent/US20240082373",
  "relatedPatents": []
}