{
  "patent_number": "US 20240075116",
  "country": "US",
  "title": "RNA Instructions for Cancer-Fighting Vaccines",
  "original_title": "Rna encoding a tumor antigen",
  "summary": "This patent describes specific RNA molecules designed to carry instructions for making proteins found on cancer cells, which can then be used to create vaccines or treatments that teach the body's immune system to fight cancer.",
  "what_it_does": "This patent describes an RNA molecule that contains at least one coding sequence. This coding sequence holds the genetic blueprint for a specific tumor antigen, which is a protein found on cancer cells. Claim 2 lists many examples of these tumor antigens, such as Her2/neu or MAGE-A3. The RNA can be an mRNA, a viral RNA, or a replicon RNA (claim 5). To make the RNA more effective, it can be modified, for instance, by increasing its G/C content or adapting its codons to human usage, which helps cells make more of the desired protein without changing the protein itself (claim 7). This specially designed RNA can then be used in compositions, vaccines, or kits to treat or prevent cancer.",
  "what_it_does_not_cover": [
    "Does not cover RNA that encodes antigens for infectious diseases like viruses or bacteria, focusing specifically on tumor antigens.",
    "Does not cover DNA-based vaccines or therapies, as the claims are directed to RNA molecules.",
    "Does not cover RNA that lacks specific modifications like increased G/C content or codon adaptation for improved expression, if such modifications are claimed as essential features.",
    "Does not cover protein-based cancer treatments where the protein itself is administered, rather than RNA instructions for making the protein.",
    "Does not cover RNA encoding tumor antigens not listed in the extensive group provided in claim 2, or variants outside the scope of the claimed fragments or variants."
  ],
  "filed": "2023-03-13",
  "granted": null,
  "expires": "2043-03-13",
  "status": "active",
  "holder": "Curevac SE",
  "holder_url": "https://patentbrief.org/company/curevac-se",
  "inventors": [
    {
      "name": "Ingmar Hoerr",
      "url": "https://patentbrief.org/inventor/ingmar-hoerr"
    },
    {
      "name": "Mariola Fotin-Mleczek",
      "url": "https://patentbrief.org/inventor/mariola-fotin-mleczek"
    }
  ],
  "times_cited": 0,
  "tags": [
    "biotech",
    "pharmaceutical",
    "oncology",
    "gene_editing"
  ],
  "abstract": "The present invention relates to an RNA encoding a tumor antigen. In particular, the present invention relates to RNA suitable for treatment and/or prophylaxis of cancer and related diseases. The present invention concerns such RNA as well as compositions, vaccines and kits comprising the RNA. Furthermore, the present invention relates to the RNA, compositions, vaccines or kits as disclosed herein for use in the treatment and/or prophylaxis of cancer and related diseases.",
  "url": "https://patentbrief.org/patent/us/20240075116/rna-encoding-a-tumor-antigen",
  "markdown_url": "https://patentbrief.org/patent/us/20240075116/rna-encoding-a-tumor-antigen/md",
  "google_patents_url": "https://patents.google.com/patent/US20240075116",
  "relatedPatents": []
}