{
  "patent_number": "US 20230136960",
  "country": "US",
  "title": "How a Specific mRNA Vaccine for COVID-19 is Designed",
  "original_title": "Novel MRNA-Based COVID-19 Multi-Valent Vaccine and Methods of Scaled Production of the Same",
  "summary": "This patent describes specific messenger RNA (mRNA) sequences designed to teach the body to fight the COVID-19 virus by producing parts of the virus, like its spike protein, to trigger an immune response.",
  "what_it_does": "This technology describes a messenger RNA (mRNA) molecule that carries instructions for human cells to make specific parts of the COVID-19 coronavirus. Specifically, the mRNA includes one or more 'coding regions' that tell cells to produce a 'peptide' (a small protein) derived from the COVID-19 virus, as detailed in claim 1. These peptides can include the virus's 'spike protein' (claim 4), the 'receptor-binding motif' (RBM) (claim 6), the 'nucleocapsid protein' (NCP) (claim 8), or the 'FuPep region' of the spike protein (claim 10). The mRNA also includes specific structural features like a 5' N7-methylguanine cap (claim 12) and untranslated regions (UTRs) from *Xenopus laevis* (African clawed frog) (claim 14), which help the mRNA function effectively in the body. For example, an mRNA molecule described here might instruct your cells to produce the COVID-19 spike protein, which then trains your immune system to recognize and fight the real virus.",
  "what_it_does_not_cover": [
    "Does not cover non-mRNA vaccine technologies, such as traditional protein-based, inactivated virus, or viral vector vaccines.",
    "Does not cover mRNA vaccines designed to target viruses or pathogens other than the COVID-19 coronavirus.",
    "Does not cover mRNA sequences that encode for COVID-19 peptides significantly different from those specified by SEQ ID NOs. 4-6, 12-15, and 17, or their variants with less than 95% sequence identity.",
    "Does not cover mRNA constructs that lack a 5' N7-methylguanine cap or the specific 5' and 3' untranslated regions (UTRs) as described in the claims.",
    "Does not cover mRNA that does not include a signal coding sequence, such as an IgE signal coding sequence, if that feature is present."
  ],
  "filed": "2021-03-19",
  "granted": null,
  "expires": "2041-03-19",
  "status": "active",
  "holder": "Natures Toolbox",
  "holder_url": "https://patentbrief.org/company/natures-toolbox",
  "inventors": [
    {
      "name": "Alexander Koglin",
      "url": "https://patentbrief.org/inventor/alexander-koglin"
    },
    {
      "name": "Michael Humbert",
      "url": "https://patentbrief.org/inventor/michael-humbert"
    }
  ],
  "times_cited": 1,
  "tags": [
    "biotech",
    "pharmaceutical",
    "gene_editing",
    "telecommunications"
  ],
  "abstract": "The inventive technology includes a novel immunostimulatory RNA vaccine for the COVID-19 coronavirus. In one preferred aspect, the inventive technology includes a novel mRNA sequence encoding at least one antigenic peptide or protein comprising or consisting of a COVID-19 coronavirus protein or a fragment or variant thereof.",
  "url": "https://patentbrief.org/patent/us/20230136960/novel-mrna-based-covid-19-multi-valent-vaccine-and-methods-of-scaled-production-",
  "markdown_url": "https://patentbrief.org/patent/us/20230136960/novel-mrna-based-covid-19-multi-valent-vaccine-and-methods-of-scaled-production-/md",
  "google_patents_url": "https://patents.google.com/patent/US20230136960",
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}