{
  "patent_number": "US 20220304938",
  "country": "US",
  "title": "Tiny Lipid Balls for Precise, Better-Absorbed Cannabinoid Medicine",
  "original_title": "Lipid nanoparticle compositions and methods as carriers of cannabinoids in standardized precision-metered dosage forms",
  "summary": "This patent describes a drug delivery system using tiny lipid nanoparticles to encapsulate cannabinoids, making them easier for the body to absorb and allowing for precise, smaller doses.",
  "what_it_does": "This patent describes a drug delivery system that uses very small structures called nanoparticles to deliver medicine. Each nanoparticle has a single outer layer of essential phospholipids that surrounds liquid lipids and the drug, which in this case are cannabinoids (Claim 1). These nanoparticles are specifically sized, ranging from 50 to 150 nanometers (Claim 1), and are designed to provide a consistent, accurate dose of the drug. The system increases how much of the drug the body absorbs, called bioavailability, by 2 to 8 times compared to non-encapsulated forms (Claim 9). This means a patient can take 2 to 8 times less medicine to get the same effect, potentially reducing side effects (Claim 10, Claim 11). For example, a sublingual (under the tongue) cannabinoid product using these nanoparticles could deliver a precise, effective dose with fewer adverse reactions.",
  "what_it_does_not_cover": [
    "Does not cover nanoparticle structures that contain surfactants, as specified in claim 3.",
    "Does not cover drug delivery systems where the phospholipid content is outside the 5-30% weight/volume range (claim 1).",
    "Does not cover nanoparticle structures with a particle size distribution outside the 50 to 150 nm range (claim 1).",
    "Does not cover systems where the drug is not encapsulated within a single layer of essential phospholipids (claim 1).",
    "Does not cover drug delivery systems that do not achieve a 2-fold to 8-fold increase in bioavailability or decrease in dose (claims 9 and 10)."
  ],
  "filed": "2022-06-16",
  "granted": null,
  "expires": "2042-06-16",
  "status": "active",
  "holder": "Nanosphere Health Sciences",
  "holder_url": "https://patentbrief.org/company/nanosphere-health-sciences",
  "inventors": [
    {
      "name": "Richard Clark Kaufman",
      "url": "https://patentbrief.org/inventor/richard-clark-kaufman"
    }
  ],
  "times_cited": 0,
  "tags": [
    "biotech",
    "pharmaceutical",
    "healthcare",
    "materials"
  ],
  "abstract": "This disclosure teaches phospholipid nanoparticle compositions of cannabinoids formed from phospholipids and simpler lipids in an unfired sequential process that encapsulate a high concentration of cannabinoids, and create standardized precision-metered dosage forms of cannabinoids; yielding an increase cannabinoid transport across hydrophobic mucosa; increase the bioavailability of the cannabinoid 2-fold to 8-fold, decrease the dose of cannabinoids 2-fold to 8-fold less than an amount of cannabinoids needed to illicit the same therapeutic effect compared to raw and non-encapsulated cannabinoids; where the nanoparticle dynamic structure reduces the adverse effects of cannabinoids; and enable safe more efficacious cannabinoid therapy.",
  "url": "https://patentbrief.org/patent/us/20220304938/lipid-nanoparticle-compositions-and-methods-as-carriers-of-cannabinoids-in-stand",
  "markdown_url": "https://patentbrief.org/patent/us/20220304938/lipid-nanoparticle-compositions-and-methods-as-carriers-of-cannabinoids-in-stand/md",
  "google_patents_url": "https://patents.google.com/patent/US20220304938",
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}