{
  "patent_number": "US 20220283184",
  "country": "US",
  "title": "Diagnosing Brain Diseases by Measuring a Protein in Blood or Urine",
  "original_title": "Novel Diagnostic Marker for Creutzfeldt-Jakob Disease and Alzheimer's Disease",
  "summary": "This patent describes a method for diagnosing brain diseases like Alzheimer's and Creutzfeldt-Jakob disease by measuring the amount of a specific protein called beta-synuclein in non-spinal fluid samples such as blood or urine.",
  "what_it_does": "This patent describes a way to diagnose diseases linked to brain cell connection breakdown, known as synaptic degeneration, by measuring the concentration of a protein called beta-synuclein in a patient's sample (Claim 1). Importantly, the method specifically covers samples that are not cerebrospinal fluid (CSF), preferring samples like blood, serum, urine, saliva, or plasma (Claims 2, 3). The method is performed outside the body, or 'ex vivo' (Claim 4). It can be used to diagnose or assess the status of conditions such as Alzheimer's disease, Creutzfeldt-Jakob disease, traumatic brain injury, or stroke (Claim 5). For example, a doctor could take a blood serum sample from a patient, use a technique like quantitative mass spectrometry or single-molecule arrays (Simoa) to measure beta-synuclein (Claims 7, 10), and then compare the level to a specific cut-off value, such as 10 pg/ml for Alzheimer's or 39.8 pg/ml for Creutzfeldt-Jakob disease, to help make a diagnosis (Claims 8, 9).",
  "what_it_does_not_cover": [
    "Does not cover diagnostic methods that rely solely on cerebrospinal fluid (CSF) samples.",
    "Does not cover diagnostic tests performed directly inside a living human or animal body.",
    "Does not cover using other biomarkers besides beta-synuclein for diagnosing these specific diseases.",
    "Does not cover methods of *treating* the diseases, only diagnosing, assessing, or monitoring their progression."
  ],
  "filed": "2020-08-12",
  "granted": null,
  "expires": "2040-08-12",
  "status": "active",
  "holder": "Individual",
  "holder_url": "https://patentbrief.org/company/individual",
  "inventors": [
    {
      "name": "Markus Otto",
      "url": "https://patentbrief.org/inventor/markus-otto"
    },
    {
      "name": "Patrick Öckl",
      "url": "https://patentbrief.org/inventor/patrick-ckl"
    },
    {
      "name": "Steffen Halbgebauer",
      "url": "https://patentbrief.org/inventor/steffen-halbgebauer"
    }
  ],
  "times_cited": 2,
  "tags": [
    "biotech",
    "pharmaceutical",
    "diagnostics",
    "medical_devices"
  ],
  "abstract": "The present invention relates to method of diagnosis of diseases associated with synaptic degeneration, in particular of Creutzfeldt-Jakob-Disease or Alzheimer's Disease, and to the use of β-synuclein as a biomarker for diagnosing or assessing the status of diseases associated with synaptic degeneration, in particular of Creutzfeldt-Jakob-Disease or Alzheimer's Disease.",
  "url": "https://patentbrief.org/patent/us/20220283184/novel-diagnostic-marker-for-creutzfeldt-jakob-disease-and-alzheimers-disease",
  "markdown_url": "https://patentbrief.org/patent/us/20220283184/novel-diagnostic-marker-for-creutzfeldt-jakob-disease-and-alzheimers-disease/md",
  "google_patents_url": "https://patents.google.com/patent/US20220283184",
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}