{
  "patent_number": "US 20210301031",
  "country": "US",
  "title": "Targeted Cancer Drugs Using Antibodies and Polymer Scaffolds",
  "original_title": "Napi2b-targeted antibody-drug conjugates and methods of use thereof",
  "summary": "This patent describes a new way to deliver powerful cancer drugs directly to tumor cells using a specific antibody attached to a special polymer, aiming to reduce side effects.",
  "what_it_does": "This patent describes a special molecule called an antibody-drug conjugate (ADC) designed to deliver therapeutic agents, which are powerful drugs, directly to cancer cells. The ADC works by using an isolated antibody that specifically attaches to a protein called SLC34A2, also known as NaPi2b, found on the outside of certain tumor cells (Claim 1). Connected to this antibody are one or more \"D-carrying polymeric scaffolds.\" These scaffolds are made of a material called poly(1-hydroxymethylethylene hydroxymethyl-formal) (PHF) and hold the therapeutic agents (D) (Claim 1). The drugs are attached to the scaffold using a \"biodegradable bond\" (Claim 1), meaning the bond breaks inside the tumor cell, releasing the drug to do its work. For example, this system could deliver a chemotherapy drug directly to a lung cancer cell that has the NaPi2b protein on its surface.",
  "what_it_does_not_cover": [
    "Does not cover antibody-drug conjugates that target proteins other than SLC34A2 (NaPi2b).",
    "Does not cover ADCs that use a polymeric scaffold different from poly(1-hydroxymethylethylene hydroxymethyl-formal) (PHF).",
    "Does not cover ADCs where the therapeutic agent is not released via a biodegradable bond as described in the claims.",
    "Does not cover ADCs where the total number of polymer scaffolds connected to the antibody is more than 10 (Claim 1).",
    "Does not cover ADCs where the antibody does not have the specific amino acid sequences for its binding regions (CDRs) as detailed in Claim 2."
  ],
  "filed": "2021-01-20",
  "granted": null,
  "expires": "2041-01-20",
  "status": "active",
  "holder": "Mersana Therapeutics",
  "holder_url": "https://patentbrief.org/company/mersana-therapeutics",
  "inventors": [
    {
      "name": "Natalya D. Bodyak",
      "url": "https://patentbrief.org/inventor/natalya-d-bodyak"
    },
    {
      "name": "Peter U. Park",
      "url": "https://patentbrief.org/inventor/peter-u-park"
    },
    {
      "name": "Aleksandr V. Yurkovetskiy",
      "url": "https://patentbrief.org/inventor/aleksandr-v-yurkovetskiy"
    },
    {
      "name": "Laura L. POLING",
      "url": "https://patentbrief.org/inventor/laura-l-poling"
    },
    {
      "name": "Donald A. Bergstrom",
      "url": "https://patentbrief.org/inventor/donald-a-bergstrom"
    },
    {
      "name": "Timothy B. Lowinger",
      "url": "https://patentbrief.org/inventor/timothy-b-lowinger"
    }
  ],
  "times_cited": 3,
  "tags": [
    "biotech",
    "pharmaceutical",
    "oncology"
  ],
  "abstract": "This disclosure provides NaPi2b-targeted antibody-drug conjugates (e.g., NaPi2b-targeted antibody-polymer-drug conjugates) that specifically bind to the extracellular region of SLC34A2, and to methods of using such conjugates in a variety of therapeutic, diagnostic, and prophylactic indications.",
  "url": "https://patentbrief.org/patent/us/20210301031/napi2b-targeted-antibody-drug-conjugates-and-methods-of-use-thereof",
  "markdown_url": "https://patentbrief.org/patent/us/20210301031/napi2b-targeted-antibody-drug-conjugates-and-methods-of-use-thereof/md",
  "google_patents_url": "https://patents.google.com/patent/US20210301031",
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}