{
  "patent_number": "US 20210140973",
  "country": "US",
  "title": "A Specific Antibody for Detecting Human IgG4 in Medical Tests",
  "original_title": "Anti-human igg4 monoclonal antibody and human igg4 assay reagent using said antibody",
  "summary": "This patent describes a unique lab-made antibody designed to precisely find and stick to a specific part of human IgG4, a type of immune protein, which is useful for diagnosing certain diseases.",
  "what_it_does": "This patent claims a monoclonal antibody that specifically binds to human IgG4. The antibody targets a very particular spot, or epitope, on the human IgG4 heavy chain constant region (specifically amino acid positions 221 to 327 of SEQ ID NO: 4), which must include glutamic acid at position 299, as stated in claim 1. The patent also covers methods for using this antibody to detect human IgG4 in a sample, for example, through an immunological particle agglutination inhibition method (claim 11 and 12). This detection involves the antibody binding to IgG4 in the sample, then adding an insoluble carrier with IgG4 attached, and observing if clumping (agglutination) is inhibited, which indicates the presence of IgG4 in the original sample (claim 13). The patent further includes kits containing this antibody for such detection, which can assist in diagnosing IgG4-related diseases (claim 14 and 18).",
  "what_it_does_not_cover": [
    "Does not cover antibodies that bind to other types of human immunoglobulins like IgG1, IgG2, or IgG3.",
    "Does not cover antibodies that bind to a different region or epitope on human IgG4, especially if it lacks glutamic acid at position 299.",
    "Does not cover detection methods for human IgG4 that do not use this specific monoclonal antibody or its bivalent forms.",
    "Does not cover detection methods that are not based on the principle of immunological particle agglutination inhibition.",
    "Does not cover diagnostic methods for IgG4-related diseases that do not rely on detecting human IgG4 levels."
  ],
  "filed": "2018-07-05",
  "granted": null,
  "expires": "2038-07-05",
  "status": "active",
  "holder": "Nitto Boseki Co",
  "holder_url": "https://patentbrief.org/company/nitto-boseki-co",
  "inventors": [
    {
      "name": "Haruka KASHIWAGURA",
      "url": "https://patentbrief.org/inventor/haruka-kashiwagura"
    },
    {
      "name": "Yuya TERUUCHI",
      "url": "https://patentbrief.org/inventor/yuya-teruuchi"
    },
    {
      "name": "Kazumitsu INAGAKI",
      "url": "https://patentbrief.org/inventor/kazumitsu-inagaki"
    },
    {
      "name": "Yuri MATSUKI",
      "url": "https://patentbrief.org/inventor/yuri-matsuki"
    },
    {
      "name": "Daisuke Sasaki",
      "url": "https://patentbrief.org/inventor/daisuke-sasaki"
    }
  ],
  "times_cited": 2,
  "tags": [
    "biotech",
    "pharmaceutical",
    "diagnostics",
    "medical_devices"
  ],
  "abstract": "Provided are: a monoclonal antibody against human IgG4, for which the epitope is present in the CH3 of human IgG4 given by SEQ ID NO: 4; a hybridoma that produces the monoclonal antibody; a method for detecting IgG4 using the monoclonal antibody; and a kit used in this method.",
  "url": "https://patentbrief.org/patent/us/20210140973/anti-human-igg4-monoclonal-antibody-and-human-igg4-assay-reagent-using-said-anti",
  "markdown_url": "https://patentbrief.org/patent/us/20210140973/anti-human-igg4-monoclonal-antibody-and-human-igg4-assay-reagent-using-said-anti/md",
  "google_patents_url": "https://patents.google.com/patent/US20210140973",
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}