{
  "patent_number": "US 20200371093",
  "country": "US",
  "title": "Checking if Brain Injury Drugs Work Using Saliva or Urine",
  "original_title": "Prognostic and Diagnostic Glycan-Based Biomarkers of Brain Damage",
  "summary": "This patent describes a method to determine if a drug for brain injury is effective by measuring specific sugar molecules in a patient's saliva or urine samples over time.",
  "what_it_does": "This patent describes a method to evaluate how well a drug treats a brain injury. First, a pharmaceutical drug is given to a patient with a brain injury. Then, samples of the patient's urine or saliva are collected at two or more different times. These samples are tested using a 'lectin array,' which is a tool containing specific proteins called lectins, such as Galanthus nivalis (GNA) or Allium sativum (ASA). The test measures the levels of certain sugar molecules, called glycans, that bind to these lectins. If the levels of these glycans change towards what is typically found in a healthy person (a 'non-brain injury control'), the drug is identified as effective. For example, if a patient with a concussion takes a new medication, and their saliva glycan levels start to resemble those of a healthy person, the drug is considered to be working.",
  "what_it_does_not_cover": [
    "Does not cover using blood or cerebrospinal fluid samples for monitoring drug efficacy, as claims 9 and 15 specifically require urine or saliva samples.",
    "Does not cover methods that only diagnose a brain injury without also evaluating the effectiveness of a drug or monitoring treatment.",
    "Does not cover using lectins other than the specifically listed ones (GNA, ASA, NPA, PSA, DSA, PHA-L, SNA-I, HHA) to detect the glycans.",
    "Does not cover methods that do not involve comparing the measured glycan levels to those of a 'non-brain injury control' for efficacy determination.",
    "Does not cover methods that only take samples at a single time point, as the claims require samples from 'two or more time points'."
  ],
  "filed": "2020-06-26",
  "granted": null,
  "expires": "2040-06-26",
  "status": "active",
  "holder": "Medicortex Finland Oy",
  "holder_url": "https://patentbrief.org/company/medicortex-finland-oy",
  "inventors": [
    {
      "name": "Adrian Harel",
      "url": "https://patentbrief.org/inventor/adrian-harel"
    }
  ],
  "times_cited": 0,
  "tags": [
    "biotech",
    "pharmaceutical",
    "diagnostics",
    "healthcare"
  ],
  "abstract": "The present disclosure relates to glycan-based biomarkers for the diagnosis or prognosis of brain damage, such as traumatic brain injury (TBI).",
  "url": "https://patentbrief.org/patent/us/20200371093/prognostic-and-diagnostic-glycan-based-biomarkers-of-brain-damage",
  "markdown_url": "https://patentbrief.org/patent/us/20200371093/prognostic-and-diagnostic-glycan-based-biomarkers-of-brain-damage/md",
  "google_patents_url": "https://patents.google.com/patent/US20200371093",
  "relatedPatents": []
}