{
  "patent_number": "US 20190307892",
  "country": "US",
  "title": "Targeting Drugs to Specific Body Tissues Using ApoE3-Coated Nanoparticles",
  "original_title": "Targeted drug delivery and therapeutic methods using apo-e modified lipid nanoparticles",
  "summary": "This patent describes a method to deliver drugs or diagnostic agents precisely to target cells or tissues, including the brain, by packaging them inside tiny fat particles (lipid nanoparticles) coated with a special protein called ApoE3.",
  "what_it_does": "This patent details a method for improving how therapeutic agents reach specific cells or tissues in the body. It uses a lipid nanoparticle (a tiny fat-based sphere) that carries a drug or diagnostic agent inside (Claim 1). The key is that this nanoparticle has a human recombinant apolipoprotein (ApoE3) attached to its surface, but without Polysorbate 80 (Claim 1). This ApoE3 coating helps the nanoparticle get preferentially absorbed by tissues like the brain, lung, kidney, and liver that have many LDL receptors (Claim 1). For example, the patent explains how this system can deliver a chemotherapy drug specifically to brain cancer cells by helping it cross the blood-brain barrier (Claim 10), or even an antibiotic like Amphotericin B to treat brain infections (Claim 12).",
  "what_it_does_not_cover": [
    "Does not cover lipid nanoparticles that use Polysorbate 80 in their surface coating, as the claims specifically exclude it (Claim 1).",
    "Does not cover drug delivery systems where the therapeutic agent is chemically attached (conjugated) to the nanoparticle (Claim 3).",
    "Does not cover drug delivery where the ApoE3 is not adsorbed to the surface of the nanoparticle, but perhaps integrated differently (Claim 1).",
    "Does not cover drug delivery to tissues that do not overexpress LDL receptors, unless the transport mechanism is explicitly through transcytosis independent of LDL receptor binding (Claim 1 and Claim 11).",
    "Does not cover nanoparticles that do not contain both a triglyceride and a cholesterol ester component in their lipid core (Claim 1)."
  ],
  "filed": "2018-04-04",
  "granted": null,
  "expires": "2038-04-04",
  "status": "active",
  "holder": "Eriochem Usa",
  "holder_url": "https://patentbrief.org/company/eriochem-usa",
  "inventors": [
    {
      "name": "Jose Lucio Nunez",
      "url": "https://patentbrief.org/inventor/jose-lucio-nunez"
    },
    {
      "name": "Dante SELENSCIG",
      "url": "https://patentbrief.org/inventor/dante-selenscig"
    },
    {
      "name": "Maria de los Angeles RAMIREZ",
      "url": "https://patentbrief.org/inventor/maria-de-los-angeles-ramirez"
    }
  ],
  "times_cited": 2,
  "tags": [
    "pharmaceutical",
    "biotech",
    "nanotechnology",
    "medicine",
    "drug_delivery"
  ],
  "abstract": "Methods for targeted delivery of therapeutic agents to a target cell or tissue with lipid nanoparticles comprising ApoE3. In embodiments, the invention specifically relates to targeted delivery of anticancer drugs, antibiotics, antifungal drugs, and diagnostic contrast agents, and associated treatment and diagnostic methods. In embodiments, diseases/conditions treated include those associated with over-expression of LDL receptors.",
  "url": "https://patentbrief.org/patent/us/20190307892/targeted-drug-delivery-and-therapeutic-methods-using-apo-e-modified-lipid-nanopa",
  "markdown_url": "https://patentbrief.org/patent/us/20190307892/targeted-drug-delivery-and-therapeutic-methods-using-apo-e-modified-lipid-nanopa/md",
  "google_patents_url": "https://patents.google.com/patent/US20190307892",
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}