{
  "patent_number": "US 20190046446",
  "country": "US",
  "title": "How Special Nanoparticles Deliver Cancer Drugs Directly to Tumors",
  "original_title": "Apo-e modified lipid nanoparticles for drug delivery to targeted tissues and therapeutic methods",
  "summary": "This patent describes tiny fat-based particles, called lipid nanoparticles, designed to carry cancer drugs directly to tumor cells using a special protein (ApoE3) on their surface, avoiding a common, potentially problematic ingredient.",
  "what_it_does": "This patent describes a tiny, engineered package called a lipid nanoparticle for delivering therapeutic agents. This nanoparticle has a core made of fats like cholesterol ester and triglycerides (Claim 1, 4), surrounded by a phospholipid layer. A key feature is the human recombinant ApoE3 protein bonded to its surface (Claim 1), which acts like a guide to target specific cells. Importantly, this ApoE3 bonding happens without using Polysorbate 80 (Claim 1), an ingredient sometimes associated with adverse reactions. The nanoparticle is precisely sized (between 20 and 150 nm) and has specific electrical and uniformity properties (Claim 1). For example, it can carry an anticancer drug like Docetaxel (Claim 10) and deliver it more effectively to cancer cells, showing a lower IC50 and higher selectivity compared to the drug's original formulation (Claim 10, 11).",
  "what_it_does_not_cover": [
    "Lipid nanoparticles that use Polysorbate 80 to bond ApoE3 to their surface (Claim 1).",
    "Nanoparticles outside the specified size range of 20 to 150 nanometers (Claim 1).",
    "Nanoparticles with a Z-potential outside the range of -25 to -5 millivolts (Claim 1).",
    "Nanoparticles with a PDI dispersion value outside the range of 0.08 to 0.30 (Claim 1).",
    "Drug delivery systems that do not incorporate human recombinant ApoE3 as the apolipoprotein component (Claim 1).",
    "Nanoparticles where the therapeutic agent is not dissolved within the lipid core (Claim 7)."
  ],
  "filed": "2017-09-28",
  "granted": null,
  "expires": "2037-09-28",
  "status": "active",
  "holder": "Eriochem Usa",
  "holder_url": "https://patentbrief.org/company/eriochem-usa",
  "inventors": [
    {
      "name": "Jose Lucio Nunez",
      "url": "https://patentbrief.org/inventor/jose-lucio-nunez"
    },
    {
      "name": "Dante SELENSCIG",
      "url": "https://patentbrief.org/inventor/dante-selenscig"
    },
    {
      "name": "Maria de los Angeles RAMIREZ",
      "url": "https://patentbrief.org/inventor/maria-de-los-angeles-ramirez"
    }
  ],
  "times_cited": 8,
  "tags": [
    "pharmaceutical",
    "biotech",
    "drug_delivery",
    "oncology"
  ],
  "abstract": "Lipid nanoparticles and methods of making and using the same, including pharmaceutical compositions and kits, and the targeted delivery of drugs in various treatment methods. The nanoparticle formulation includes phospholipids, triglycerides, cholesterol, cholesteryl ester, apolipoprotein E3 (ApoE3), and a lipophilic therapeutic agent.",
  "url": "https://patentbrief.org/patent/us/20190046446/apo-e-modified-lipid-nanoparticles-for-drug-delivery-to-targeted-tissues-and-the",
  "markdown_url": "https://patentbrief.org/patent/us/20190046446/apo-e-modified-lipid-nanoparticles-for-drug-delivery-to-targeted-tissues-and-the/md",
  "google_patents_url": "https://patents.google.com/patent/US20190046446",
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}