{
  "patent_number": "US 12735703",
  "country": "US",
  "title": "How Oligonucleotides Target C9orf72 for Brain Diseases",
  "original_title": "Oligonucleotide compositions and methods of use thereof",
  "summary": "This patent describes using special genetic molecules called oligonucleotides to treat brain diseases like ALS and FTD by targeting a specific gene called C9orf72.",
  "what_it_does": "The patent describes specific oligonucleotide compositions designed to interact with the C9orf72 gene. These oligonucleotides are intended to be used in methods for treating conditions linked to this gene, such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). For example, a patient with C9orf72-associated ALS could receive a composition containing these oligonucleotides to potentially reduce the harmful effects of the gene.",
  "what_it_does_not_cover": [
    "Does not cover treatments for ALS or FTD that are not linked to the C9orf72 gene mutation.",
    "Does not cover therapies for C9orf72-associated conditions that use non-oligonucleotide approaches, such as small molecule drugs or gene editing tools like CRISPR.",
    "Does not cover diagnostic methods for identifying the C9orf72 mutation.",
    "Does not cover oligonucleotides designed to target genes other than C9orf72."
  ],
  "filed": "2020-10-05",
  "granted": "2026-09-15",
  "expires": null,
  "status": "active",
  "holder": null,
  "holder_url": null,
  "inventors": [],
  "times_cited": 0,
  "tags": [
    "biotech",
    "pharmaceutical",
    "gene_editing"
  ],
  "abstract": "Among other things, the present disclosure provides C9orf72 oligonucleotides, compositions, and methods thereof. In some embodiments, the present disclosure provides methods for treating C9orf72-associated conditions, disorders or diseases, such as amyotrophic lateral sclerosis and frontotemporal dementia.",
  "url": "https://patentbrief.org/patent/us/12735703/oligonucleotide-compositions-and-methods-of-use-thereof",
  "markdown_url": "https://patentbrief.org/patent/us/12735703/oligonucleotide-compositions-and-methods-of-use-thereof/md",
  "google_patents_url": "https://patents.google.com/patent/US12735703",
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}