# Using Antibodies and CAR-T Cells to Fight MUC1-C Expressing Cancers

> This patent describes specific antibodies and engineered immune cells (CAR-T) designed to target and treat cancers that produce a particular protein called MUC1-C.

- **Patent:** US 12735503
- **Original title:** Anti-MUC1-C antibodies and CAR-T structures
- **Granted:** 2026
- **Status:** Active
- **Times cited:** 0
- **Field:** biotech, pharmaceutical, gene_editing, oncology

## What it does

The patent discloses anti-MUC1-C antibodies, including a type referred to as UniAbs™, and CAR-T structures. These are designed to recognize and bind to the MUC1-C protein, which is found on certain cancer cells. The patent also covers methods for creating these antibodies and CAR-T structures, as well as pharmaceutical compositions containing them. The core purpose is to use these specialized biological tools to treat diseases, specifically cancers, that are characterized by the presence of MUC1-C. For example, a patient with a MUC1-C expressing tumor could potentially receive a therapy made from these CAR-T cells to help their immune system attack the cancer.

## What it does NOT cover

- Does not cover therapies targeting cancer markers or proteins other than MUC1-C.
- Does not cover cancer treatments that do not involve antibodies or CAR-T structures.
- Does not cover methods for diagnosing MUC1-C expressing disorders, focusing only on treatment.
- Does not cover the use of non-antibody-based molecules or different types of cell therapies to target MUC1-C.

## The clever bit

The clever bit is the specific targeting of the MUC1-C protein using a dual approach of specialized antibodies and CAR-T cells. MUC1-C plays a role in cancer cell survival and growth, so precisely hitting this target with both antibody-based and cell-based therapies offers a potentially potent way to combat tumors that rely on this protein.

## Real-world examples

1. CAR-T cell therapies (e.g., Kymriah, Yescarta)
2. Antibody-drug conjugates (ADCs)
3. Targeted cancer immunotherapies
4. Treatments for solid tumors expressing MUC1-C

## Why it matters

MUC1-C is a protein often found on the surface of aggressive cancer cells, making it a significant target for new cancer treatments. This patent combines two powerful approaches: highly specific antibodies and CAR-T cell therapy, which reprograms a patient's own immune cells to fight cancer. Developing targeted therapies like these is crucial for improving outcomes in hard-to-treat cancers.

## Frequently asked questions

### What does Using Antibodies and CAR-T Cells to Fight MUC1-C Expressing Cancers cover?

This patent describes specific antibodies and engineered immune cells (CAR-T) designed to target and treat cancers that produce a particular protein called MUC1-C.

### When does this patent expire?

This patent is expected to expire on September 15, 2046, when the invention enters the public domain.

### What problem does this patent solve?

MUC1-C is a protein often found on the surface of aggressive cancer cells, making it a significant target for new cancer treatments. This patent combines two powerful approaches: highly specific antibodies and CAR-T cell therapy, which reprograms a patient's own immune cells to fight cancer. Developing targeted therapies like these is crucial for improving outcomes in hard-to-treat cancers.

### What does this patent NOT cover?

Does not cover therapies targeting cancer markers or proteins other than MUC1-C.

**Full plain-English explainer:** https://patentbrief.org/patent/us/12735503/anti-muc1-c-antibodies-and-car-t-structures

**Original patent:** https://patents.google.com/patent/US12735503

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_Source: PatentBrief — https://patentbrief.org. Patent facts are from public records; the plain-English explanation is PatentBrief's._