{
  "patent_number": "US 12735497",
  "country": "US",
  "title": "Bispecific Antibodies for Targeting Alzheimer's Disease in the Brain",
  "original_title": "Bispecific anti-human a-beta/human transferrin receptor antibodies and methods of use",
  "summary": "This patent describes special antibodies designed to cross into the brain and target amyloid-beta, a protein linked to Alzheimer's disease.",
  "what_it_does": "This patent describes special antibodies that are 'bispecific,' meaning they are engineered to attach to two different targets at the same time. One target is human A-beta, a protein linked to Alzheimer's disease. The other target is the human transferrin receptor, a protein found on the blood-brain barrier, which is the protective shield around the brain. The patent provides these specific antibodies and methods for using them, likely to help deliver treatment to the brain for conditions like Alzheimer's disease.",
  "what_it_does_not_cover": [
    "Antibodies that only target one specific protein (monospecific antibodies), rather than two different ones simultaneously.",
    "Bispecific antibodies that target different combinations of proteins, not specifically human A-beta and the human transferrin receptor.",
    "Methods of treating Alzheimer's disease that do not involve using antibodies to cross the blood-brain barrier via the transferrin receptor.",
    "Other types of treatments for neurodegenerative diseases, such as small molecule drugs or gene therapies, that are not antibody-based.",
    "Antibodies that target A-beta but do not use the transferrin receptor to enter the brain.",
    "Antibodies that target the transferrin receptor but do not also target A-beta."
  ],
  "filed": "2023-04-10",
  "granted": "2026-09-15",
  "expires": null,
  "status": "active",
  "holder": null,
  "holder_url": null,
  "inventors": [],
  "times_cited": 0,
  "tags": [
    "biotech",
    "pharmaceutical",
    "neuroscience"
  ],
  "abstract": "Herein are provided bispecific anti-human A-beta/human transferrin receptor antibodies and methods of using the same.",
  "url": "https://patentbrief.org/patent/us/12735497/bispecific-anti-human-a-betahuman-transferrin-receptor-antibodies-and-methods",
  "markdown_url": "https://patentbrief.org/patent/us/12735497/bispecific-anti-human-a-betahuman-transferrin-receptor-antibodies-and-methods/md",
  "google_patents_url": "https://patents.google.com/patent/US12735497",
  "relatedPatents": [
    {
      "patentNumber": "12735507",
      "countryCode": "US",
      "title": "Antibodies to Target Tau Protein in Brain Diseases",
      "url": "https://patentbrief.org/patent/us/12735507/antibodies-recognizing-tau"
    },
    {
      "patentNumber": "10138293",
      "countryCode": "US",
      "title": "How Roche Engineers Antibodies to Target Two Different Diseases Simultaneously",
      "url": "https://patentbrief.org/patent/us/10138293/opdivo-nivolumab"
    },
    {
      "patentNumber": "11193946",
      "countryCode": "US",
      "title": "Detecting Alzheimer's Risk Early with a Blood Test and Brain Scan",
      "url": "https://patentbrief.org/patent/us/11193946/blood-biomarker-for-discerning-beta-amyloid-accumulation-in-brain"
    },
    {
      "patentNumber": "20220283184",
      "countryCode": "US",
      "title": "Diagnosing Brain Diseases by Measuring a Protein in Blood or Urine",
      "url": "https://patentbrief.org/patent/us/20220283184/novel-diagnostic-marker-for-creutzfeldt-jakob-disease-and-alzheimers-disease"
    },
    {
      "patentNumber": "7993644",
      "countryCode": "US",
      "title": "Using Antibodies to Target Tissue Factor Without Stopping Blood Clotting",
      "url": "https://patentbrief.org/patent/us/7993644/stelara-ustekinumab"
    }
  ]
}