{
  "patent_number": "US 12735425",
  "country": "US",
  "title": "Chemical Compounds to Block a Specific KRAS Cancer Gene",
  "original_title": "6,7-dihydro-pyrano[2,3-d]pyrimidine inhibitors of KRAS G12C mutant",
  "summary": "This patent describes new chemical compounds designed to stop a specific mutated protein called KRAS G12C, which is often found in various cancers, potentially offering new ways to treat the disease.",
  "what_it_does": "This patent describes new chemical compounds, generally referred to as Formula (I), and their pharmaceutically acceptable salts. These compounds are designed to stop or 'inhibit' the activity of a specific mutated protein called KRAS G12C. By blocking this protein, the compounds are intended to act as therapeutic agents to treat various types of cancer. The patent also covers pharmaceutical compositions containing these compounds and methods for using them in the therapy and prophylaxis of cancer. For example, a patient with lung cancer driven by the KRAS G12C mutation could receive a drug based on these compounds to slow or stop tumor growth. Without the specific claims, the precise chemical structures and their exact scope of protection are not detailed.",
  "what_it_does_not_cover": [
    "Does not cover inhibitors for other specific KRAS mutations, such as KRAS G12D or KRAS G12V.",
    "Does not cover cancer treatments that target different proteins or biological pathways unrelated to KRAS G12C.",
    "Does not cover non-chemical methods of inhibiting KRAS G12C, such as gene editing or RNA interference.",
    "Does not cover compounds that do not fall under the general chemical description of Formula (I) as implied by the abstract.",
    "Does not cover treating cancers where the KRAS G12C mutation is not present."
  ],
  "filed": "2021-11-23",
  "granted": "2026-09-15",
  "expires": null,
  "status": "active",
  "holder": null,
  "holder_url": null,
  "inventors": [],
  "times_cited": 0,
  "tags": [
    "pharmaceutical",
    "biotech",
    "oncology",
    "drug_discovery"
  ],
  "abstract": "The disclosure provides compounds of Formula (I) \n     \n       \n         \n         \n             \n             \n         \n       \n         \n         \n           \n             or a pharmaceutically acceptable salt thereof, wherein W 1 , W 2 , Y, Z, C A , R 1 , R 2a , and R 2b  are as described herein. The compounds or their pharmaceutically acceptable salts can inhibit the G12C mutant of Kirsten rat sarcoma (KRAS) protein and are expected to have utility as therapeutic agents, for example, for treating cancer. The disclosure also provides pharmaceutical compositions which comprise compounds of Formula (I) or pharmaceutically acceptable salts thereof. The disclosure also relates to methods for use of the compounds or their pharmaceutically acceptable salts in the therapy and prophylaxis of cancer and for preparing pharmaceuticals for this purpose.",
  "url": "https://patentbrief.org/patent/us/12735425/67-dihydro-pyrano23-dpyrimidine-inhibitors-of-kras-g12c-mutant",
  "markdown_url": "https://patentbrief.org/patent/us/12735425/67-dihydro-pyrano23-dpyrimidine-inhibitors-of-kras-g12c-mutant/md",
  "google_patents_url": "https://patents.google.com/patent/US12735425",
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}