{
  "patent_number": "US 12735419",
  "country": "US",
  "title": "Making and Separating Specific Chemical Forms of a Drug Compound",
  "original_title": "Process for racemizing and isolating atropisomers of 7-chloro-6-fluoro-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-D]pyrimidine-2,4(1H,3H)-dione",
  "summary": "This patent describes a method to convert a specific chemical compound into a balanced mixture of its mirror-image forms and then separate one desired form, important for making medicines.",
  "what_it_does": "This patent provides a method for making and separating specific chemical forms of a complex molecule referred to as 'Compound A' (7-chloro-6-fluoro-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-D]pyrimidine-2,4(1H,3H)-dione). One process involves heating a composition containing the (P)-form of Compound A, or its salt, with a solvent to a high temperature, specifically between 250° C. and 350° C. This heating step converts the pure (P)-form into a mixture of both mirror-image forms, known as racemized Compound A. Additionally, the patent describes a process for isolating the desired (P)-Compound A from a mixture that includes a tartrate, which helps in the separation. It also details a method for isolating the free acid of a tartrate or its hydrate from a composition containing the tartrate, (P)-Compound A, and an organic solvent. For example, a pharmaceutical company could use this process to ensure a drug contains only the effective (P)-Compound A, avoiding the inactive or harmful mirror-image form.",
  "what_it_does_not_cover": [
    "Does not cover racemization processes for chemical compounds other than 7-chloro-6-fluoro-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-D]pyrimidine-2,4(1H,3H)-dione.",
    "Does not cover racemization of (P)-compound A at temperatures outside the specified range of 250° C. to 350° C.",
    "Does not cover isolation methods for (P)-compound A that do not involve the use of a tartrate.",
    "Does not cover separation of other types of isomers, such as enantiomers that are not atropisomers, or diastereomers.",
    "Does not cover processes for isolating (P)-compound A from compositions that do not contain a tartrate."
  ],
  "filed": "2021-10-06",
  "granted": "2026-09-15",
  "expires": null,
  "status": "active",
  "holder": null,
  "holder_url": null,
  "inventors": [],
  "times_cited": 0,
  "tags": [
    "pharmaceutical",
    "chemical_synthesis",
    "biotech"
  ],
  "abstract": "Provided herein is a process comprising heating a composition comprising (P)-compound A or a salt thereof and a solvent to a temperature of 250° C. to 350° C. to form racemized compound A. Also provided is a process for isolating (P)-compound A from a composition comprising (P)-compound A and a tartrate, as described herein. Further provided herein, is a process for isolating a free acid of a tartrate or a hydrate thereof from a composition comprising a tartrate, (P)-compound A, and an organic solvent.",
  "url": "https://patentbrief.org/patent/us/12735419/process-for-racemizing-and-isolating-atropisomers-of",
  "markdown_url": "https://patentbrief.org/patent/us/12735419/process-for-racemizing-and-isolating-atropisomers-of/md",
  "google_patents_url": "https://patents.google.com/patent/US12735419",
  "relatedPatents": []
}