{
  "patent_number": "US 12735369",
  "country": "US",
  "title": "Making Deuterium-Labeled Chemicals Precisely with Metal Catalysts",
  "original_title": "Selective transition metal catalyzed deuterium incorporation into alkyne and alkene functionalities",
  "summary": "This patent describes new ways to precisely add a special type of hydrogen called deuterium to specific parts of chemical molecules using metal helpers, making them useful for medicines or research.",
  "what_it_does": "Based on the abstract, this patent describes new chemical methods for precisely adding deuterium, a heavier version of hydrogen, to specific parts of molecules. These 'transition metal catalyzed methods' are designed to incorporate deuterium into 'alkyne and alkene functionalities' – which are specific types of chemical bonds. The methods are 'regioselective', meaning the deuterium goes to a particular spot, and 'enantioselective', meaning it produces mostly one specific 3D mirror-image form of the molecule. This precision allows for creating 'isomerically and/or enantiomerically pure or enriched deuterated compounds'. The abstract also notes these methods can be adapted to make fluorinated compounds. For example, a drug developer could use this method to swap a hydrogen for a deuterium at a specific carbon atom in a drug candidate, ensuring the new molecule has a precise structure for improved stability.",
  "what_it_does_not_cover": [
    "Does not cover methods for adding deuterium that do not use transition metal catalysts.",
    "Does not cover deuterium incorporation into chemical structures other than alkynes and alkenes.",
    "Does not cover methods that produce a random mix of deuterium locations or mirror-image forms.",
    "Does not cover the creation of fluorinated compounds if the method is not a modification of the described deuterium incorporation techniques."
  ],
  "filed": "2021-11-01",
  "granted": "2026-09-15",
  "expires": null,
  "status": "active",
  "holder": null,
  "holder_url": null,
  "inventors": [],
  "times_cited": 0,
  "tags": [
    "pharmaceutical",
    "biotech",
    "chemicals",
    "materials",
    "research_and_development"
  ],
  "abstract": "Disclosed herein are deuterated compounds and transition metal catalyzed methods for making deuterated compounds. The disclosed methods are regioselective and enantioselective and may be utilized to prepare isomerically and/or enantiomerically pure or enriched deuterated compounds. The disclosed methods also may be modified in order to prepared fluorinated compounds.",
  "url": "https://patentbrief.org/patent/us/12735369/selective-transition-metal-catalyzed-deuterium-incorporation-into-alkyne-and",
  "markdown_url": "https://patentbrief.org/patent/us/12735369/selective-transition-metal-catalyzed-deuterium-incorporation-into-alkyne-and/md",
  "google_patents_url": "https://patents.google.com/patent/US12735369",
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