{
  "patent_number": "US 12734246",
  "country": "US",
  "title": "Antibodies that Deliver Drugs to Cells Using Transferrin Receptors",
  "original_title": "Anti-transferrin receptor (TFR) antibody, encoding nucleic acid thereof and method of use thereof to deliver an oligonucleotide to a subject",
  "summary": "This patent describes special antibodies that bind to transferrin receptors on cells to deliver molecular payloads, such as genetic material, for therapeutic purposes.",
  "what_it_does": "The patent focuses on specific antibodies designed to attach to a protein called the transferrin receptor (TFR), particularly transferrin receptor 1, found on the surface of many cells. Once the antibody binds to this receptor, it can deliver a 'molecular payload' into the cell. This payload is covalently linked, meaning it's strongly attached to the antibody. The abstract specifically mentions delivering an oligonucleotide, which is a type of genetic material, into a subject. This mechanism allows for targeted delivery of drugs or genetic therapies to specific cells or tissues.",
  "what_it_does_not_cover": [
    "Does not cover antibodies that bind to cell receptors other than the transferrin receptor.",
    "Does not cover drug delivery systems that do not use an antibody as the primary targeting agent.",
    "Does not cover delivery of payloads that are not covalently linked to the antibody.",
    "Does not cover delivery of payloads that are not oligonucleotides, unless they are also 'molecular payloads' linked to the antibody."
  ],
  "filed": "2021-07-09",
  "granted": "2026-09-15",
  "expires": null,
  "status": "active",
  "holder": null,
  "holder_url": null,
  "inventors": [],
  "times_cited": 0,
  "tags": [
    "biotech",
    "pharmaceutical",
    "gene_editing"
  ],
  "abstract": "Aspects of the disclosure relate to antibodies that bind to transferrin receptor (e.g., transferrin receptor 1) and complexes comprising the antibody covalently linked to a molecular payload. Methods of using the antibodies are also provided.",
  "url": "https://patentbrief.org/patent/us/12734246/anti-transferrin-receptor-tfr-antibody-encoding-nucleic-acid-thereof-and",
  "markdown_url": "https://patentbrief.org/patent/us/12734246/anti-transferrin-receptor-tfr-antibody-encoding-nucleic-acid-thereof-and/md",
  "google_patents_url": "https://patents.google.com/patent/US12734246",
  "relatedPatents": []
}