{
  "patent_number": "US 12734234",
  "country": "US",
  "title": "Bacteria-Based Vaccines for HIV and Other Infections",
  "original_title": "Compositions and methods for preventing and treating virus infection",
  "summary": "This patent describes using specially engineered bacteria, like Salmonella, to create vaccines that teach the body to fight off viruses like HIV by showing it specific parts of the virus on the bacteria's surface.",
  "what_it_does": "This patent describes a method for creating vaccine candidates using bacteria. Specifically, it focuses on HIV, where bacteria are engineered to express (display) parts of the HIV virus, called MPER-derived antigens, on their outer surfaces. This display uses a natural bacterial mechanism called Gram autotransporters. When these engineered bacteria are used to immunize mice, the mice produce antibodies in their blood and vaginal washes that can bind to the bacteria. Crucially, at least one of these bacterial candidates also causes the production of antibodies that can neutralize (stop) HIV activity. This approach includes using both killed whole bacteria and live *Salmonella* to deliver these antigens.",
  "what_it_does_not_cover": [
    "Vaccines that do not use bacteria as the primary delivery platform for antigens.",
    "Vaccines that rely on traditional methods like inactivated viruses, attenuated viruses, viral vectors, or mRNA technology.",
    "Vaccine candidates targeting parts of the HIV virus other than MPER-derived antigens.",
    "Vaccines that present antigens internally within a cell rather than on the bacterial surface.",
    "Bacterial vaccine platforms that do not utilize Gram autotransporters for surface antigen expression."
  ],
  "filed": "2019-08-27",
  "granted": "2026-09-15",
  "expires": null,
  "status": "active",
  "holder": null,
  "holder_url": null,
  "inventors": [],
  "times_cited": 0,
  "tags": [
    "biotech",
    "pharmaceutical",
    "infectious_diseases",
    "vaccine_development"
  ],
  "abstract": "Disclosed herein are bacteria-based HIV MPER vaccine candidates, as well as bacteria-based candidates for other viruses and for bacteria. The HIV vaccine candidates express MPER-derived antigens on their surfaces using Gram autotransporters. The surface-expressed MPER antigens bind several different MPER-directed anti-HIV Broadly Neutralizing Monoclonal Antibodies. When the bacteria expressing the MPER-derived antigens on their surfaces are used to immunize mice they elicit the production of sera and vaginal wash material that bind the bacteria expressing the MPER antigens. At least one of the bacteria expressing MPER-derived antigens on their surfaces elicits the production of sera with anti-HIV neutralizing activity. Killed whole cell and live  Salmonella  expressing the MPER derived antigens on their surfaces constitute new approaches to HIV vaccine develop that is plausible and that could ultimately yield an inexpensive, globally appropriate candidate vaccine that could be rapidly produced and deployed largely using currently available technology.",
  "url": "https://patentbrief.org/patent/us/12734234/compositions-and-methods-for-preventing-and-treating-virus-infection",
  "markdown_url": "https://patentbrief.org/patent/us/12734234/compositions-and-methods-for-preventing-and-treating-virus-infection/md",
  "google_patents_url": "https://patents.google.com/patent/US12734234",
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}