{
  "patent_number": "US 12734174",
  "country": "US",
  "title": "Treating Lewy Body Dementia by Targeting Patients Without Tau Protein",
  "original_title": "Treatment of a selective population of patients having dementia with Lewy bodies",
  "summary": "This patent describes a method to treat a specific type of Dementia with Lewy Bodies in patients who don't have a lot of another brain protein called tau, using a special kind of drug.",
  "what_it_does": "The patent provides methods and compositions for treating subjects diagnosed with Dementia with Lewy Bodies (DLB). It specifically focuses on a population of patients who have DLB but do not show 'substantial tau pathology' in their brains, meaning they don't have a significant buildup of tau protein. These specific patients are shown to respond particularly well to treatment with a 'selective p38α mitogen activated protein kinase (MAPK) inhibitor'. For example, a patient diagnosed with DLB who tests negative for high levels of tau protein could be given a drug that specifically blocks the p38α MAPK pathway.",
  "what_it_does_not_cover": [
    "Does not cover treating Dementia with Lewy Bodies in patients who do have substantial tau pathology, as they are shown to be less responsive.",
    "Does not cover treatments for other forms of dementia, such as Alzheimer's disease, unless they also present as DLB without substantial tau pathology.",
    "Does not cover general p38α MAPK inhibitors; it specifies a selective p38α MAPK inhibitor, implying a need for targeted action.",
    "Does not cover treatments for DLB that are not based on inhibiting p38α MAPK."
  ],
  "filed": "2025-08-28",
  "granted": "2026-09-15",
  "expires": null,
  "status": "active",
  "holder": null,
  "holder_url": null,
  "inventors": [],
  "times_cited": 0,
  "tags": [
    "biotech",
    "pharmaceutical",
    "neuroscience"
  ],
  "abstract": "The present invention provides methods and compositions for the treatment of subjects that have Dementia with Lewy Bodies (DLB) but have no substantial tau pathology. Subjects with DLB that have no substantial tau pathology are shown to be particularly responsive to treatment with a selective p38α mitogen activated protein kinase (MAPK) inhibitor compared to subjects with DLB that have substantial tau pathology.",
  "url": "https://patentbrief.org/patent/us/12734174/treatment-of-a-selective-population-of-patients-having-dementia-with-lewy-bodies",
  "markdown_url": "https://patentbrief.org/patent/us/12734174/treatment-of-a-selective-population-of-patients-having-dementia-with-lewy-bodies/md",
  "google_patents_url": "https://patents.google.com/patent/US12734174",
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}