{
  "patent_number": "US 12734138",
  "country": "US",
  "title": "Tiny Epinephrine Particles for Fast-Dissolving Under-Tongue Tablets",
  "original_title": "Epinephrine fine particles and methods for use thereof",
  "summary": "This patent describes new compositions of extremely small epinephrine particles designed for fast-dissolving tablets that are absorbed under the tongue, aiming to treat severe allergic reactions or cardiac events more effectively with a lower dose.",
  "what_it_does": "This patent describes compositions that include epinephrine in the form of very tiny particles, specifically nanoparticles or nanocrystals, and microparticles or microcrystals. These fine particles are incorporated into pharmaceutical formulations like orally-disintegrating and fast-disintegrating tablets. The primary mechanism is to significantly increase how much epinephrine is absorbed into the bloodstream when placed under the tongue, known as sublingual bioavailability. For example, a person experiencing anaphylaxis could place one of these tablets under their tongue, allowing the epinephrine to enter their system quickly and reduce the required dose compared to other methods.",
  "what_it_does_not_cover": [
    "Does not cover epinephrine delivered by injection, such as through an auto-injector like an EpiPen.",
    "Does not cover epinephrine formulations that are not in the form of fine particles (nanoparticles, nanocrystals, microparticles, or microcrystals).",
    "Does not cover epinephrine delivered through traditional pills that are swallowed and absorbed in the digestive tract.",
    "Does not cover epinephrine delivery methods that do not specifically aim to increase sublingual bioavailability.",
    "Does not cover other active pharmaceutical ingredients besides epinephrine in these fine particle formulations."
  ],
  "filed": "2022-01-24",
  "granted": "2026-09-15",
  "expires": null,
  "status": "active",
  "holder": null,
  "holder_url": null,
  "inventors": [],
  "times_cited": 0,
  "tags": [
    "pharmaceutical",
    "biotech",
    "consumer_electronics"
  ],
  "abstract": "Compositions include epinephrine fine particles, including epinephrine nanoparticles or nanocrystals and epinephrine microparticles or microcrystals, and methods for therapeutic use of the compositions for the treatment of conditions responsive to epinephrine such as a cardiac event or an allergic reaction, particularly anaphylaxis. The epinephrine fine particles can be incorporated into orally-disintegrating and fast-disintegrating tablet pharmaceutical formulations and can significantly increase the sublingual bioavailability of epinephrine, and thereby reduce the epinephrine dose required.",
  "url": "https://patentbrief.org/patent/us/12734138/epinephrine-fine-particles-and-methods-for-use-thereof",
  "markdown_url": "https://patentbrief.org/patent/us/12734138/epinephrine-fine-particles-and-methods-for-use-thereof/md",
  "google_patents_url": "https://patents.google.com/patent/US12734138",
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}