{
  "patent_number": "US 12590172",
  "country": "US",
  "title": "How to Find Antibodies That Only Detect Bound Drug Targets",
  "original_title": "Complex-specific antibodies and antibody fragments and its use",
  "summary": "This patent describes a method to create and use special antibodies that only detect when a therapeutic or diagnostic antibody is bound to its target, ignoring both the target and the unbound antibody.",
  "what_it_does": "This invention provides a method for creating and using unique antibodies, called \"complex-specific antibodies.\" These special antibodies are designed to only attach to a \"complex\" (Claim 1) – which is formed when a \"cognate antibody\" (the original antibody being studied) is already bound to its \"antigen\" (its target molecule). The method involves screening a library of potential antibodies (Claim 1a) and then isolating specific ones that bind only to this complex, explicitly not binding to the cognate antibody alone or the antigen alone (Claim 1c). Once identified, these complex-specific antibodies can be used to contact a sample (Claim 1d) and detect how much of the original cognate antibody is actually bound to its target, for example, to monitor a therapeutic antibody drug's activity in a patient's body.",
  "what_it_does_not_cover": [
    "Does not cover antibodies that bind to the cognate antibody when it is not attached to its antigen.",
    "Does not cover antibodies that bind to the antigen when it is not attached to the cognate antibody.",
    "Does not cover detection methods where the identifying antibody binds to both the complex and the individual cognate antibody or antigen.",
    "Does not cover methods for detecting the complex that do not involve first screening a library of antibodies as described in Claim 1a.",
    "Does not cover detection methods that do not use an isolated monoclonal antibody or functional fragment thereof."
  ],
  "filed": "2023-03-30",
  "granted": "2026-03-31",
  "expires": "2043-03-30",
  "status": "active",
  "holder": "Morphosys",
  "holder_url": "https://patentbrief.org/company/morphosys",
  "inventors": [
    {
      "name": "Stefan Haertle",
      "url": "https://patentbrief.org/inventor/stefan-haertle"
    },
    {
      "name": "Christian Frisch",
      "url": "https://patentbrief.org/inventor/christian-frisch"
    },
    {
      "name": "Achim Knappik",
      "url": "https://patentbrief.org/inventor/achim-knappik"
    }
  ],
  "times_cited": 0,
  "tags": [
    "biotech",
    "pharmaceutical",
    "diagnostics",
    "healthcare"
  ],
  "abstract": "The present invention provides antibodies and fragments thereof that specifically detect the complex of a specific cognate antigen-binding moiety, in particular antibodies, and its antigen. The antibodies of the present disclosure do not bind either said cognate antigen binding moiety or said antigen alone and this can be used e.g. to directly detect antigen-bound antigen-binding moieties. Further disclosed are methods for production and use of said antibodies and antibody fragments.",
  "url": "https://patentbrief.org/patent/us/12590172/complex-specific-antibodies-and-antibody-fragments-and-its-use",
  "markdown_url": "https://patentbrief.org/patent/us/12590172/complex-specific-antibodies-and-antibody-fragments-and-its-use/md",
  "google_patents_url": "https://patents.google.com/patent/US12590172",
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}