{
  "patent_number": "US 12419940",
  "country": "US",
  "title": "New Nanoparticles for Delivering Large RNA Medicines to Cells",
  "original_title": "Compositions and methods for modified dendrimer nanoparticle delivery",
  "summary": "This patent describes a specific type of modified dendrimer nanoparticle designed to efficiently deliver large RNA molecules, like replicating RNA, into cells for therapeutic, prophylactic, or diagnostic purposes, notably without using cholesterol.",
  "what_it_does": "This patent describes a method for delivering various agents, such as medicines or diagnostic tools, to a subject's cells using a special particle called a modified dendrimer nanoparticle (MDNP). The MDNP is built from three main parts: specific types of dendrimers (like poly(ethylene imine) or poly(propylene imine) from claim 1), a particular amphiphilic polymer (1,2-dimystistoyl-sn-glycerol-3-phosphoethanolamine-N-[methoxy (polyethylene glycol)-2000] from claim 1), and one or more nucleic acids (like replicating RNA or messenger RNA from claim 11) that are encapsulated inside. A key feature is that this nanoparticle specifically does not include cholesterol (claim 1). For example, these nanoparticles can deliver replicating RNAs that express proteins in cells, potentially at different rates if multiple RNAs are used (claim 3), which could be used to trigger an immune response against cancer or infectious agents (claim 15).",
  "what_it_does_not_cover": [
    "Does not cover nanoparticles that include cholesterol in their composition, as claim 1 explicitly states the nanoparticle 'does not include cholesterol'.",
    "Does not cover delivery systems using dendrimers outside the specific types and generations listed in claim 1, such as poly(ethylene imine) dendrimers beyond seven generations.",
    "Does not cover nanoparticles using amphiphilic polymers other than the specific 1,2-dimystistoyl-sn-glycerol-3-phosphoethanolamine-N-[methoxy (polyethylene glycol)-2000] mentioned in claim 1.",
    "Does not cover methods of delivery where the nucleic acids are not encapsulated within the dendrimer nanoparticle, such as direct injection of naked RNA."
  ],
  "filed": "2021-03-10",
  "granted": "2025-09-23",
  "expires": "2041-03-10",
  "status": "active",
  "holder": "Massachusetts Institute of Technology",
  "holder_url": "https://patentbrief.org/company/massachusetts-institute-of-technology",
  "inventors": [
    {
      "name": "Hidde Ploegh",
      "url": "https://patentbrief.org/inventor/hidde-ploegh"
    },
    {
      "name": "Daniel G. Anderson",
      "url": "https://patentbrief.org/inventor/daniel-g-anderson"
    },
    {
      "name": "Jasdave S. Chahal",
      "url": "https://patentbrief.org/inventor/jasdave-s-chahal"
    },
    {
      "name": "Tyler E. Jacks",
      "url": "https://patentbrief.org/inventor/tyler-e-jacks"
    },
    {
      "name": "Robert S. Langer",
      "url": "https://patentbrief.org/inventor/robert-s-langer"
    },
    {
      "name": "Omar F. Khan",
      "url": "https://patentbrief.org/inventor/omar-f-khan"
    },
    {
      "name": "David A. Canner",
      "url": "https://patentbrief.org/inventor/david-a-canner"
    }
  ],
  "times_cited": 0,
  "tags": [
    "biotech",
    "pharmaceutical",
    "gene_editing",
    "materials",
    "telecommunications"
  ],
  "abstract": "Compositions and methods for modified dendrimer nanoparticle (“MDNP”) delivery of therapeutic, prophylactic and/or diagnostic agent such as large repRNA molecules to the cells of a subject have been developed. MDNPs efficiently drive proliferation of antigen-specific T cells against intracellular antigen, and potentiate antigen-specific antibody responses. MDNPs can be multiplexed to deliver two or more different repRNAs to modify expression kinetics of encoded antigens and to simultaneous deliver repRNAs and mRNAs including the same UTR elements that promote expression of encoded antigens.",
  "url": "https://patentbrief.org/patent/us/12419940/compositions-and-methods-for-modified-dendrimer-nanoparticle-delivery",
  "markdown_url": "https://patentbrief.org/patent/us/12419940/compositions-and-methods-for-modified-dendrimer-nanoparticle-delivery/md",
  "google_patents_url": "https://patents.google.com/patent/US12419940",
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}