{
  "patent_number": "US 12365678",
  "country": "US",
  "title": "How to Manufacture a Complex Cancer-Fighting Drug Molecule",
  "original_title": "Pharmaceutical process for the preparation of 4-{4-[(3R)-3-methylmorpholin-4-yl]-6-[1-((R)-S-methylsulfonimidoyl) cyclopropyl]pyrimidin-2-yl}-1H-pyrrolo[2,3-b] pyridine and intermediates",
  "summary": "A detailed chemical recipe for mass-producing a specific cancer-fighting molecule, including the intermediate building blocks needed to construct it efficiently.",
  "what_it_does": "This patent describes a multi-step chemical manufacturing process for a specific pharmaceutical compound known as Formula (I), which is used to treat cancer. It outlines how to build the molecule by creating smaller 'intermediate' chemical structures, such as those labeled Formula (II) through (XIII), and then linking them together. The process uses specific chemical reactions, including palladium-catalyzed coupling and the use of oxidative enzymes, to assemble the final drug structure. By defining these specific pathways, the patent allows for the large-scale production of the drug with higher efficiency than previous laboratory-scale methods.",
  "what_it_does_not_cover": [
    "Does not cover the final drug molecule itself, as that was previously disclosed in earlier patents.",
    "Does not cover general chemical reactions not specifically applied to the synthesis of these identified intermediates.",
    "Does not cover alternative synthetic routes that do not utilize the specific intermediates or reaction steps claimed in the patent.",
    "Does not cover the medical use or clinical application of the drug."
  ],
  "filed": "2019-12-17",
  "granted": "2025-07-22",
  "expires": null,
  "status": "active",
  "holder": "AstraZeneca AB",
  "holder_url": "https://patentbrief.org/company/astrazeneca-ab",
  "inventors": [
    {
      "name": "Phillip Anthony Inglesby",
      "url": "https://patentbrief.org/inventor/phillip-anthony-inglesby"
    },
    {
      "name": "Lucinda Victoria Jackson",
      "url": "https://patentbrief.org/inventor/lucinda-victoria-jackson"
    },
    {
      "name": "David Pranay Dave",
      "url": "https://patentbrief.org/inventor/david-pranay-dave"
    },
    {
      "name": "Mark Andrew Graham",
      "url": "https://patentbrief.org/inventor/mark-andrew-graham"
    },
    {
      "name": "Katie Grace Cooper",
      "url": "https://patentbrief.org/inventor/katie-grace-cooper"
    },
    {
      "name": "Gary Michael Noonan",
      "url": "https://patentbrief.org/inventor/gary-michael-noonan"
    }
  ],
  "times_cited": 0,
  "tags": [
    "pharmaceutical",
    "biotech"
  ],
  "abstract": "The present disclosure concerns the large-scale manufacture of pharmaceutical compounds, and novel intermediates for use in the manufacture. International Patent Application WO2011154737 discloses morpholine pyrimidines useful for treating cancer, processes for their preparation and pharmaceutical compositions thereof. In particular, WO2011154737 discloses, as experimental Example 2.02 on page 60, the compound 4-{4-[(3R)-3-methylmorpholin-4-yl]-6-[1-((R)—S-methylsulfonimidoyl)cyclopropyl]pyrimidin-2-yl}-1H-pyrrolo[2,3-b]pyridine (hereafter referred to as the compound of Formula (I)). The structure of the compound of Formula (I) is shown below. A synthetic route to the compound of Formula (I) is described at pages 51 to 57, 66 and 67 of WO2011154737, and is summarised below in Scheme 1.",
  "url": "https://patentbrief.org/patent/us/12365678/raptor-production",
  "markdown_url": "https://patentbrief.org/patent/us/12365678/raptor-production/md",
  "google_patents_url": "https://patents.google.com/patent/US12365678",
  "relatedPatents": []
}