{
  "patent_number": "US 12350368",
  "country": "US",
  "title": "Delivering Large Gene Editing Tools into Cells with Hybrid Virus-Lipid Packages",
  "original_title": "Delivery of large payloads",
  "summary": "This patent describes a sophisticated delivery system that combines parts of a virus with a fat bubble (liposome) to efficiently transport large molecules, like CRISPR gene-editing components, into specific cells.",
  "what_it_does": "This patent describes a \"particle delivery system\" (Claim 1) designed to get large molecules into cells. It uses a \"composite virus particle\" which is a tiny structure made of a specific lipid, a piece of a virus's outer shell (a \"virus capsid protein\"), and another large protein or peptide that isn't part of the virus shell (a \"non-capsid protein or peptide\"). This composite particle is then attached to a \"liposome\" (a small fat bubble) that has a \"targeting moiety\" — a special tag that helps it find and attach to specific cells (Claim 1). The system can carry a \"CRISPR system component\" (Claim 3) or other large proteins up to a megadalton in size (Claim 9). For example, this system could be used to deliver the Cas9 protein, a key part of CRISPR gene editing, into a specific type of cell in the body, like a liver cell, by using a targeting moiety that recognizes that cell type.",
  "what_it_does_not_cover": [
    "Does not cover delivery systems that use only a virus or only a liposome, as it requires a \"composite virus particle\" adsorbed to a \"liposome\" (Claim 1).",
    "Does not cover systems using lipids outside the specific list provided in Claim 1 (e.g., EC16-63, 80-O14B, etc.).",
    "Does not cover liposomes without a \"targeting moiety,\" which is a specific component for guiding the delivery (Claim 1).",
    "Does not cover delivery of very small molecules or payloads that are not proteins or peptides, as the \"non-capsid protein or peptide\" is described as having a molecular weight up to a megadalton and specifically mentions CRISPR proteins (Claim 9).",
    "Does not cover attachment methods between the composite virus particle and the liposome that are not hydrophobic or electrostatic interactions (Claim 2)."
  ],
  "filed": "2018-04-16",
  "granted": "2025-07-08",
  "expires": "2038-04-16",
  "status": "active",
  "holder": "Massachusetts Institute of Technology",
  "holder_url": "https://patentbrief.org/company/massachusetts-institute-of-technology",
  "inventors": [
    {
      "name": "Qiaobing Xu",
      "url": "https://patentbrief.org/inventor/qiaobing-xu"
    },
    {
      "name": "Feng Zhang",
      "url": "https://patentbrief.org/inventor/feng-zhang"
    },
    {
      "name": "Sourav CHOUDHURY",
      "url": "https://patentbrief.org/inventor/sourav-choudhury"
    }
  ],
  "times_cited": 0,
  "tags": [
    "biotech",
    "gene_editing",
    "pharmaceutical",
    "materials"
  ],
  "abstract": "The disclosure includes non-naturally occurring or engineered CRISPR systems and proteins, associated with a delivery system comprising a virus component and a lipid component. The disclosure includes CRISPR proteins associated with capsid proteins, e.g., AAV VP1VP2, and/or VP3, on the surface of or internal to the AAV, along with compositions, systems and complexes involving the AAV-CRISPR protein, nucleic acid molecules and vectors encoding the same, deliver}-systems, and uses therefor.",
  "url": "https://patentbrief.org/patent/us/12350368/delivery-of-large-payloads",
  "markdown_url": "https://patentbrief.org/patent/us/12350368/delivery-of-large-payloads/md",
  "google_patents_url": "https://patents.google.com/patent/US12350368",
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}