{
  "patent_number": "US 12121527",
  "country": "US",
  "title": "Making Cancer-Fighting Antibody Drugs Safer with Precise Attachment",
  "original_title": "Anthracycline-based antibody drug conjugates having high in vivo tolerability",
  "summary": "This patent describes a specific way to build antibody-drug conjugates (ADCs) for cancer treatment by precisely attaching chemotherapy drugs to antibodies to make them safer inside the body.",
  "what_it_does": "The patent describes an antibody drug conjugate (ADC) designed to deliver chemotherapy more safely. It combines an antibody (or a fragment of one) with an anthracycline-based small molecule, which is a type of chemotherapy drug (Claim 1). The key is how they are linked: the small molecule is *exclusively* attached to the C-terminus of the antibody's light chain constant region (Claim 1). This attachment uses a linker that includes a peptidic sequence, often formed after a sortase enzyme cleaves a recognition motif (Claim 3, 9). For example, the patent specifies that two anthracycline molecules are linked, one to each light chain C-terminus (Claim 1), ensuring a precise drug-to-antibody ratio. This design aims for improved tolerability in the body, particularly for treating neoplastic diseases like breast cancer (Claim 10, 11).",
  "what_it_does_not_cover": [
    "ADCs where the drug is attached to parts of the antibody other than the light chain constant region C-terminus (Claim 1).",
    "ADCs that use chemotherapy drugs *not* based on anthracycline (Claim 1, \"anthracycline-based small molecule\").",
    "ADCs where the drug is linked via a method that does not involve a sortase enzyme or a peptidic sequence linker (Claim 1, 3, 9).",
    "ADCs with a drug-to-antibody ratio different from 1 or 2, specifically if there are more than two anthracycline-based small molecules per antibody (Claim 1, \"two light chain constant region C-termini and two anthracycline-based small molecules\").",
    "ADCs where the linker does not comprise a peptidic sequence (Claim 1)."
  ],
  "filed": "2020-07-10",
  "granted": "2024-10-22",
  "expires": "2040-07-10",
  "status": "active",
  "holder": "NBE Therapeutics AG",
  "holder_url": "https://patentbrief.org/company/nbe-therapeutics-ag",
  "inventors": [
    {
      "name": "Roger Beerli",
      "url": "https://patentbrief.org/inventor/roger-beerli"
    },
    {
      "name": "Remy GEBLEUX",
      "url": "https://patentbrief.org/inventor/remy-gebleux"
    },
    {
      "name": "Ulf Grawunder",
      "url": "https://patentbrief.org/inventor/ulf-grawunder"
    }
  ],
  "times_cited": 0,
  "tags": [
    "biotech",
    "pharmaceutical",
    "drug_delivery"
  ],
  "abstract": "The present invention relates to antibody drug conjugates (ADCs) presenting improved properties of in vivo tolerability.",
  "url": "https://patentbrief.org/patent/us/12121527/anthracycline-based-antibody-drug-conjugates-having-high-in-vivo-tolerability",
  "markdown_url": "https://patentbrief.org/patent/us/12121527/anthracycline-based-antibody-drug-conjugates-having-high-in-vivo-tolerability/md",
  "google_patents_url": "https://patents.google.com/patent/US12121527",
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}