{
  "patent_number": "US 12043837",
  "country": "US",
  "title": "Boosting Gene Editing Success in Plants with Special Proteins",
  "original_title": "Methods for improving genome engineering and regeneration in plant",
  "summary": "This patent describes how to make genetic changes in plant cells much more successful by adding specific 'booster' proteins or their genetic instructions alongside the gene-editing tools.",
  "what_it_does": "This patent details methods for significantly improving the success rate of genome engineering in plant cells. It achieves this by introducing specific 'booster polypeptides' (proteins) identified by amino acid sequences like SEQ ID NO: 2 or 48, or nucleic acids (DNA/RNA) that encode these boosters, into the plant cell. These boosters are delivered along with the desired new gene (transgene) or genome engineering components. For example, if a scientist wants to insert a gene for pest resistance into a corn plant cell, adding these booster proteins would make that insertion process much more efficient, leading to more successfully modified cells. The method can also include other helper polypeptides like PLETHORA 5 (PLT5) or PLETHORA 7 (PLT7) to further enhance the modification process.",
  "what_it_does_not_cover": [
    "Does not cover genome engineering or genetic modification in non-plant cells, such as animal or human cells.",
    "Does not cover genetic modification methods that do not use the specific booster polypeptides of SEQ ID NO: 2 or 48, or sequences at least 93% identical to them.",
    "Does not cover the genome engineering components themselves, only their use in combination with the specified booster polypeptides.",
    "Does not cover methods where the booster polypeptide or its encoding nucleic acid is not introduced into the plant cell.",
    "Does not cover genetic modification without the goal of increasing efficiency via these specific boosters."
  ],
  "filed": "2019-06-14",
  "granted": "2024-07-23",
  "expires": "2039-06-14",
  "status": "active",
  "holder": "KWS SAAT SE and Co KGaA",
  "holder_url": "https://patentbrief.org/company/kws-saat-se-and-co-kgaa",
  "inventors": [
    {
      "name": "Ling Meng",
      "url": "https://patentbrief.org/inventor/ling-meng"
    }
  ],
  "times_cited": 1,
  "tags": [
    "biotech",
    "agriculture",
    "gene_editing"
  ],
  "abstract": "This document relates to methods and materials for genome engineering in eukaryotic cells, and particularly to methods for increasing genome engineering (i.e. transformation or genome editing) efficiency via delivery of one or more booster polypeptides, and boost genes, with genome engineering components.",
  "url": "https://patentbrief.org/patent/us/12043837/methods-for-improving-genome-engineering-and-regeneration-in-plant",
  "markdown_url": "https://patentbrief.org/patent/us/12043837/methods-for-improving-genome-engineering-and-regeneration-in-plant/md",
  "google_patents_url": "https://patents.google.com/patent/US12043837",
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}