{
  "patent_number": "US 12006349",
  "country": "US",
  "title": "How a Specific Peptide Can Train Your Immune System to Fight Cancer",
  "original_title": "Peptides and combination of peptides for use in immunotherapy against various tumors",
  "summary": "This patent describes a specific nine-amino-acid peptide, ALFETLIQL, and its use in compositions to help the immune system's T cells recognize and attack tumor cells.",
  "what_it_does": "This patent claims a specific peptide, ALFETLIQL (identified as SEQ ID NO: 214), which is a short chain of amino acids. This peptide is designed to be in a pharmaceutically acceptable salt form, like a chloride or acetate salt (Claim 1, 3, 4). The patent explains that this peptide can bind to a special protein on cell surfaces called an MHC class-I molecule, and when it's bound, it can be recognized by CD8 T cells, which are a type of immune cell that kills infected or cancerous cells (Claim 2). The patent also covers compositions that include this peptide along with a pharmaceutically acceptable carrier, which is like a safe delivery vehicle for the body (Claim 5). These compositions can also include other helper substances called adjuvants, such as IL-2 or IL-12, to boost the immune response (Claim 8). For example, this peptide could be part of a vaccine designed to teach a patient's immune system to target specific cancer cells displaying this peptide.",
  "what_it_does_not_cover": [
    "Does not cover any other peptide sequence for cancer immunotherapy besides ALFETLIQL (SEQ ID NO: 214).",
    "Does not cover methods of cancer treatment that do not involve this specific ALFETLIQL peptide or its compositions.",
    "Does not cover the use of the ALFETLIQL peptide if it's not in a pharmaceutically acceptable salt form or part of a composition with a carrier.",
    "Does not cover the use of this peptide if it does not bind to an MHC class-I molecule or is not recognized by CD8 T cells.",
    "Does not cover immunotherapy approaches that do not rely on stimulating the patient's own T cells to recognize tumor-associated peptides."
  ],
  "filed": "2021-08-06",
  "granted": "2024-06-11",
  "expires": "2041-08-06",
  "status": "active",
  "holder": "Immatics Biotechnologies",
  "holder_url": "https://patentbrief.org/company/immatics-biotechnologies",
  "inventors": [
    {
      "name": "Oliver Schoor",
      "url": "https://patentbrief.org/inventor/oliver-schoor"
    },
    {
      "name": "Harpreet Singh",
      "url": "https://patentbrief.org/inventor/harpreet-singh"
    },
    {
      "name": "Andrea MAHR",
      "url": "https://patentbrief.org/inventor/andrea-mahr"
    },
    {
      "name": "Lea STEVERMANN",
      "url": "https://patentbrief.org/inventor/lea-stevermann"
    },
    {
      "name": "Toni Weinschenk",
      "url": "https://patentbrief.org/inventor/toni-weinschenk"
    },
    {
      "name": "Jens FRITSCHE",
      "url": "https://patentbrief.org/inventor/jens-fritsche"
    }
  ],
  "times_cited": 1,
  "tags": [
    "biotech",
    "pharmaceutical",
    "telecommunications"
  ],
  "abstract": "The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.",
  "url": "https://patentbrief.org/patent/us/12006349/peptides-and-combination-of-peptides-for-use-in-immunotherapy-against-various-tu-12006349",
  "markdown_url": "https://patentbrief.org/patent/us/12006349/peptides-and-combination-of-peptides-for-use-in-immunotherapy-against-various-tu-12006349/md",
  "google_patents_url": "https://patents.google.com/patent/US12006349",
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}