{
  "patent_number": "US 11692002",
  "country": "US",
  "title": "Making RNA for Vaccines More Consistent",
  "original_title": "RNA sequence adaptation",
  "summary": "CureVac's 2023 patent on a method to create multiple RNA strands with similar numbers of A and U nucleotides, making them easier to purify and use in vaccines.",
  "what_it_does": "This patent describes a way to prepare RNA strands for things like vaccines. First, you get the instructions (coding sequences) for at least two different RNA molecules, each between 800 and 20,000 units long. The key step is altering the original RNA sequences so that the new versions have a similar count of 'A' and 'U' building blocks, differing by no more than 50 from each other. Then, these 'harmonized' RNA molecules are made. Finally, a mixture of these harmonized RNA molecules is analyzed or purified using a chromatography technique, like High-Performance Liquid Chromatography (HPLC). For example, this could be used to make multiple mRNA strands that each code for a different part of a virus, like influenza antigens, ensuring they are consistent for purification.",
  "what_it_does_not_cover": [
    "Methods that do not involve adapting the number of A and/or U nucleotides in the RNA sequence.",
    "Methods where the RNA species are not between 800 and 20,000 nucleotides long.",
    "Methods where the harmonized RNA species have more than 50 difference in their A and U nucleotide counts.",
    "Purification or analysis methods that do not use chromatography.",
    "RNA sequences that are not intended for use in vaccines or therapeutic treatments."
  ],
  "filed": "2018-11-08",
  "granted": "2023-07-04",
  "expires": "2038-11-08",
  "status": "active",
  "holder": "Curevac SE",
  "holder_url": "https://patentbrief.org/company/curevac-se",
  "inventors": [
    {
      "name": "Dominik VAHRENHORST",
      "url": "https://patentbrief.org/inventor/dominik-vahrenhorst"
    },
    {
      "name": "Tilmann Roos",
      "url": "https://patentbrief.org/inventor/tilmann-roos"
    },
    {
      "name": "Markus CONZELMANN",
      "url": "https://patentbrief.org/inventor/markus-conzelmann"
    },
    {
      "name": "Stefan Heinz",
      "url": "https://patentbrief.org/inventor/stefan-heinz"
    }
  ],
  "times_cited": 4,
  "tags": [
    "biotech",
    "pharmaceutical",
    "semiconductors"
  ],
  "abstract": "The present invention is directed to a method for modifying the retention time of RNA on a chromatographic column. The present invention also concerns a method for purifying RNA from a mixture of at least two RNA species. Furthermore, the present invention relates to a method for co-purifying at least two RNA species from a mixture of at least two RNA species. In particular, the present invention provides a method for harmonizing the numbers of A and/or U nucleotides in at least two RNA species. The present invention is also directed to RNA obtainable by said methods, a composition comprising said RNA or a vaccine comprising said RNA and methods for producing such RNA and compositions. Further, the invention concerns a kit, particularly a kit of parts, comprising the RNA, composition or vaccine. The invention is further directed to a method of treating or preventing a disorder or a disease, first and second medical uses of the RNA, composition and vaccine. Moreover, the present invention concerns a method for providing an adapted RNA sequence or an adapted RNA mixture.",
  "url": "https://patentbrief.org/patent/us/11692002/rna-sequence-adaptation",
  "markdown_url": "https://patentbrief.org/patent/us/11692002/rna-sequence-adaptation/md",
  "google_patents_url": "https://patents.google.com/patent/US11692002",
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}