{
  "patent_number": "US 11560405",
  "country": "US",
  "title": "Targeting Liver and Bile Duct Cancers with Specific Immune Cells",
  "original_title": "Peptides and combination thereof for use in the immunotherapy against cancers",
  "summary": "This patent describes a method to treat liver and bile duct cancers by using specially activated immune cells that recognize a unique protein fragment found on these cancer cells.",
  "what_it_does": "This patent claims a method for treating patients with hepatocellular carcinoma (a type of liver cancer) or bile duct cancer. The treatment involves giving the patient a composition containing activated CD8+ cytotoxic T cells. These T cells are specifically trained to recognize and bind to a particular peptide, LTDSFPLKV (SEQ ID NO: 37), when it's presented on the surface of cancer cells by an MHC class I molecule, as stated in claim 1. The patent also covers methods where the composition includes an adjuvant, such as IL-2 or IL-7, to boost the immune response (claim 2). For example, a patient with bile duct cancer could receive an infusion of these specially prepared T cells, potentially alongside an immune-boosting substance, to help their body fight the cancer.",
  "what_it_does_not_cover": [
    "Does not cover treating cancers other than hepatocellular carcinoma or bile duct cancer.",
    "Does not cover targeting peptide sequences different from LTDSFPLKV (SEQ ID NO: 37).",
    "Does not cover therapies that use immune cells other than activated CD8+ cytotoxic T cells.",
    "Does not cover methods where the target peptide is not presented in a complex with an MHC class I molecule on the cancer cell surface."
  ],
  "filed": "2022-07-08",
  "granted": "2023-01-24",
  "expires": "2042-07-08",
  "status": "active",
  "holder": "Immatics Biotechnologies",
  "holder_url": "https://patentbrief.org/company/immatics-biotechnologies",
  "inventors": [
    {
      "name": "Juliane Sarah WALZ",
      "url": "https://patentbrief.org/inventor/juliane-sarah-walz"
    },
    {
      "name": "Daniel Johannes Kowalewski",
      "url": "https://patentbrief.org/inventor/daniel-johannes-kowalewski"
    },
    {
      "name": "Hans-Georg Rammensee",
      "url": "https://patentbrief.org/inventor/hans-georg-rammensee"
    },
    {
      "name": "Markus Loeffler",
      "url": "https://patentbrief.org/inventor/markus-loeffler"
    },
    {
      "name": "Annika NELDE",
      "url": "https://patentbrief.org/inventor/annika-nelde"
    },
    {
      "name": "Moreno DI MARCO",
      "url": "https://patentbrief.org/inventor/moreno-di-marco"
    },
    {
      "name": "Stefan Stevanovic",
      "url": "https://patentbrief.org/inventor/stefan-stevanovic"
    },
    {
      "name": "Nico TRAUTWEIN",
      "url": "https://patentbrief.org/inventor/nico-trautwein"
    },
    {
      "name": "Sebastian HAEN",
      "url": "https://patentbrief.org/inventor/sebastian-haen"
    }
  ],
  "times_cited": 0,
  "tags": [
    "biotech",
    "pharmaceutical",
    "immunotherapy",
    "oncology"
  ],
  "abstract": "The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.",
  "url": "https://patentbrief.org/patent/us/11560405/peptides-and-combination-thereof-for-use-in-the-immunotherapy-against-cancers-11560405",
  "markdown_url": "https://patentbrief.org/patent/us/11560405/peptides-and-combination-thereof-for-use-in-the-immunotherapy-against-cancers-11560405/md",
  "google_patents_url": "https://patents.google.com/patent/US11560405",
  "relatedPatents": [
    {
      "patentNumber": "12168044",
      "countryCode": "US",
      "title": "Treating Liver Cancer with Specially Trained Immune Cells",
      "url": "https://patentbrief.org/patent/us/12168044/peptides-and-combination-of-peptides-for-use-in-immunotherapy-against-non-small-"
    },
    {
      "patentNumber": "11407807",
      "countryCode": "US",
      "title": "Using Specific Immune Cells to Fight Cancers Like Lung and Breast Cancer",
      "url": "https://patentbrief.org/patent/us/11407807/peptides-and-combination-of-peptides-for-use-in-immunotherapy-against-various-tu"
    },
    {
      "patentNumber": "10314897",
      "countryCode": "US",
      "title": "How a Specific Protein Fragment Can Train Immune Cells to Fight Cancer",
      "url": "https://patentbrief.org/patent/us/10314897/peptides-and-combination-of-peptides-for-use-in-immunotherapy-against-various-ca"
    },
    {
      "patentNumber": "10364282",
      "countryCode": "US",
      "title": "Training Immune Cells to Fight Specific Cancers",
      "url": "https://patentbrief.org/patent/us/10364282/peptides-and-combination-of-peptides-for-use-in-immunotherapy-against-esophageal"
    },
    {
      "patentNumber": "11542303",
      "countryCode": "US",
      "title": "How a Specific Peptide Boosts the Immune System Against Cancer",
      "url": "https://patentbrief.org/patent/us/11542303/peptides-and-combination-thereof-for-use-in-the-immunotherapy-against-cancers"
    }
  ]
}