{
  "patent_number": "US 11542303",
  "country": "US",
  "title": "How a Specific Peptide Boosts the Immune System Against Cancer",
  "original_title": "Peptides and combination thereof for use in the immunotherapy against cancers",
  "summary": "This patent describes a specific peptide sequence, KESDGFHRF, combined with immune-boosting substances and a safe delivery method, for use in treating cancer through immunotherapy.",
  "what_it_does": "This patent claims a specific recipe for a cancer treatment. It involves a particular protein fragment, called a peptide, with the exact amino acid sequence KESDGFHRF (Claim 1). This peptide is combined with an 'adjuvant,' which is a substance that helps make the immune response stronger. The patent lists several possible adjuvants, including imiquimod, GM-CSF, and various interleukins like IL-2, IL-7, IL-12, IL-15, and IL-21 (Claim 2). All these ingredients are mixed into a 'pharmaceutically acceptable carrier,' which is a safe way to deliver the medicine to a patient. For example, a composition could include the KESDGFHRF peptide, IL-2 as the adjuvant (Claim 3), and a buffer for stability (Claim 8), all within a safe liquid carrier for injection.",
  "what_it_does_not_cover": [
    "Does not cover cancer immunotherapies that use different peptide sequences than KESDGFHRF.",
    "Does not cover the peptide KESDGFHRF when administered without an adjuvant.",
    "Does not cover the peptide KESDGFHRF without a pharmaceutically acceptable carrier.",
    "Does not cover using only the listed adjuvants without the specific KESDGFHRF peptide.",
    "Does not cover non-immunotherapy treatments for cancer, such as chemotherapy alone."
  ],
  "filed": "2021-06-25",
  "granted": "2023-01-03",
  "expires": "2041-06-25",
  "status": "active",
  "holder": "Immatics Biotechnologies",
  "holder_url": "https://patentbrief.org/company/immatics-biotechnologies",
  "inventors": [
    {
      "name": "Juliane Sarah WALZ",
      "url": "https://patentbrief.org/inventor/juliane-sarah-walz"
    },
    {
      "name": "Daniel Johannes Kowalewski",
      "url": "https://patentbrief.org/inventor/daniel-johannes-kowalewski"
    },
    {
      "name": "Hans-Georg Rammensee",
      "url": "https://patentbrief.org/inventor/hans-georg-rammensee"
    },
    {
      "name": "Markus Loeffler",
      "url": "https://patentbrief.org/inventor/markus-loeffler"
    },
    {
      "name": "Annika NELDE",
      "url": "https://patentbrief.org/inventor/annika-nelde"
    },
    {
      "name": "Moreno DI MARCO",
      "url": "https://patentbrief.org/inventor/moreno-di-marco"
    },
    {
      "name": "Stefan Stevanovic",
      "url": "https://patentbrief.org/inventor/stefan-stevanovic"
    },
    {
      "name": "Nico TRAUTWEIN",
      "url": "https://patentbrief.org/inventor/nico-trautwein"
    },
    {
      "name": "Sebastian HAEN",
      "url": "https://patentbrief.org/inventor/sebastian-haen"
    }
  ],
  "times_cited": 1,
  "tags": [
    "biotech",
    "pharmaceutical",
    "immunotherapy"
  ],
  "abstract": "The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.",
  "url": "https://patentbrief.org/patent/us/11542303/peptides-and-combination-thereof-for-use-in-the-immunotherapy-against-cancers",
  "markdown_url": "https://patentbrief.org/patent/us/11542303/peptides-and-combination-thereof-for-use-in-the-immunotherapy-against-cancers/md",
  "google_patents_url": "https://patents.google.com/patent/US11542303",
  "relatedPatents": []
}