{
  "patent_number": "US 11407807",
  "country": "US",
  "title": "Using Specific Immune Cells to Fight Cancers Like Lung and Breast Cancer",
  "original_title": "Peptides and combination of peptides for use in immunotherapy against various tumors",
  "summary": "This patent describes a method to treat specific cancers, including lung, breast, and ovarian cancer, by giving patients their own immune cells (T cells) that have been trained to recognize and destroy cancer cells presenting a unique protein fragment.",
  "what_it_does": "The patent describes a way to treat certain cancers by boosting a patient's own immune system. Specifically, it involves giving a patient a group of \"activated T cells\" (a type of white blood cell) that are specially trained to kill cancer cells (Claim 1). These T cells target cancer cells that display a particular protein fragment, or \"peptide,\" with the amino acid sequence TLHDQVHLL (SEQ ID NO: 264) on their surface. The patent lists various cancers that can be treated this way, such as non-small cell lung cancer, breast cancer, and melanoma (Claim 1). The T cells are activated outside the body by showing them this specific peptide attached to a \"MHC class I molecule\" on another cell, which teaches them what to look for (Claim 2). For example, a doctor might take a patient's T cells, train them in a lab to recognize the TLHDQVHLL peptide, and then infuse these super-charged T cells back into the patient to fight their specific cancer.",
  "what_it_does_not_cover": [
    "Treating cancers that do not present the specific peptide TLHDQVHLL (SEQ ID NO: 264) on their cell surface.",
    "Immunotherapy methods that do not involve administering activated T cells (e.g., traditional chemotherapy or radiation).",
    "Activating T cells inside the body without first contacting them with an antigen-presenting cell expressing the peptide with an MHC class I molecule outside the body, as described in Claim 2.",
    "Using different peptides or protein fragments to identify and target cancer cells.",
    "Treating cancer types not explicitly listed in Claim 1, such as colon cancer or pancreatic cancer.",
    "Methods that use antibodies or soluble T-cell receptors as the primary therapeutic agent, rather than activated T cells."
  ],
  "filed": "2021-07-23",
  "granted": "2022-08-09",
  "expires": "2041-07-23",
  "status": "active",
  "holder": "Immatics Biotechnologies",
  "holder_url": "https://patentbrief.org/company/immatics-biotechnologies",
  "inventors": [
    {
      "name": "Oliver Schoor",
      "url": "https://patentbrief.org/inventor/oliver-schoor"
    },
    {
      "name": "Harpreet Singh",
      "url": "https://patentbrief.org/inventor/harpreet-singh"
    },
    {
      "name": "Andrea MAHR",
      "url": "https://patentbrief.org/inventor/andrea-mahr"
    },
    {
      "name": "Lea STEVERMANN",
      "url": "https://patentbrief.org/inventor/lea-stevermann"
    },
    {
      "name": "Toni Weinschenk",
      "url": "https://patentbrief.org/inventor/toni-weinschenk"
    },
    {
      "name": "Jens FRITSCHE",
      "url": "https://patentbrief.org/inventor/jens-fritsche"
    }
  ],
  "times_cited": 8,
  "tags": [
    "biotech",
    "pharmaceutical",
    "oncology",
    "immunotherapy"
  ],
  "abstract": "The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.",
  "url": "https://patentbrief.org/patent/us/11407807/peptides-and-combination-of-peptides-for-use-in-immunotherapy-against-various-tu",
  "markdown_url": "https://patentbrief.org/patent/us/11407807/peptides-and-combination-of-peptides-for-use-in-immunotherapy-against-various-tu/md",
  "google_patents_url": "https://patents.google.com/patent/US11407807",
  "relatedPatents": [
    {
      "patentNumber": "10314897",
      "countryCode": "US",
      "title": "How a Specific Protein Fragment Can Train Immune Cells to Fight Cancer",
      "url": "https://patentbrief.org/patent/us/10314897/peptides-and-combination-of-peptides-for-use-in-immunotherapy-against-various-ca"
    },
    {
      "patentNumber": "12168044",
      "countryCode": "US",
      "title": "Treating Liver Cancer with Specially Trained Immune Cells",
      "url": "https://patentbrief.org/patent/us/12168044/peptides-and-combination-of-peptides-for-use-in-immunotherapy-against-non-small-"
    },
    {
      "patentNumber": "10364282",
      "countryCode": "US",
      "title": "Training Immune Cells to Fight Specific Cancers",
      "url": "https://patentbrief.org/patent/us/10364282/peptides-and-combination-of-peptides-for-use-in-immunotherapy-against-esophageal"
    },
    {
      "patentNumber": "11560405",
      "countryCode": "US",
      "title": "Targeting Liver and Bile Duct Cancers with Specific Immune Cells",
      "url": "https://patentbrief.org/patent/us/11560405/peptides-and-combination-thereof-for-use-in-the-immunotherapy-against-cancers-11560405"
    },
    {
      "patentNumber": "11542303",
      "countryCode": "US",
      "title": "How a Specific Peptide Boosts the Immune System Against Cancer",
      "url": "https://patentbrief.org/patent/us/11542303/peptides-and-combination-thereof-for-use-in-the-immunotherapy-against-cancers"
    }
  ]
}