{
  "patent_number": "US 11401319",
  "country": "US",
  "title": "Training Immune Cells to Fight Specific Cancers",
  "original_title": "Peptides and combination of peptides for use in immunotherapy against esophageal cancer and other cancers",
  "summary": "This patent describes a method to treat certain cancers, like esophageal cancer, by training a patient's own immune cells in the lab to recognize and kill cancer cells that have specific protein markers.",
  "what_it_does": "This patent claims a method for treating patients with specific cancers, including esophageal cancer, non-small cell lung cancer, melanoma, and head and neck squamous cell carcinoma, particularly when these cancers produce too much of the KRT14 or KRT16 proteins containing the STYGGGLSV peptide (SEQ ID NO: 1). The treatment involves administering a population of activated T cells to the patient. These T cells are cytotoxic, meaning they kill cancer cells, and are produced by contacting CD8+ T cells with an antigen-presenting cell in a lab setting, where the antigen-presenting cell displays the STYGGGLSV peptide linked to an MHC class I molecule. This process trains the T cells to specifically target and kill the cancer cells.",
  "what_it_does_not_cover": [
    "Does not cover treating cancers that do not overexpress, or produce too much of, the KRT14 or KRT16 proteins.",
    "Does not cover T cells that are activated directly inside the patient's body; the activation must occur in a lab setting (in vitro).",
    "Does not cover using a different cancer-targeting peptide than the specific STYGGGLSV sequence (SEQ ID NO: 1).",
    "Does not cover T cells that are not of the CD8+ type, which is a specific kind of immune cell.",
    "Does not cover methods that use T cells that are not designed to directly kill cancer cells (cytotoxic T cells)."
  ],
  "filed": "2021-12-17",
  "granted": "2022-08-02",
  "expires": "2041-12-17",
  "status": "active",
  "holder": "Immatics Biotechnologies",
  "holder_url": "https://patentbrief.org/company/immatics-biotechnologies",
  "inventors": [
    {
      "name": "Oliver Schoor",
      "url": "https://patentbrief.org/inventor/oliver-schoor"
    },
    {
      "name": "Colette SONG",
      "url": "https://patentbrief.org/inventor/colette-song"
    },
    {
      "name": "Harpreet Singh",
      "url": "https://patentbrief.org/inventor/harpreet-singh"
    },
    {
      "name": "Andrea MAHR",
      "url": "https://patentbrief.org/inventor/andrea-mahr"
    },
    {
      "name": "Toni Weinschenk",
      "url": "https://patentbrief.org/inventor/toni-weinschenk"
    },
    {
      "name": "Jens FRITSCHE",
      "url": "https://patentbrief.org/inventor/jens-fritsche"
    }
  ],
  "times_cited": 1,
  "tags": [
    "biotech",
    "pharmaceutical",
    "oncology",
    "immunotherapy"
  ],
  "abstract": "The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.",
  "url": "https://patentbrief.org/patent/us/11401319/peptides-and-combination-of-peptides-for-use-in-immunotherapy-against-esophageal-11401319",
  "markdown_url": "https://patentbrief.org/patent/us/11401319/peptides-and-combination-of-peptides-for-use-in-immunotherapy-against-esophageal-11401319/md",
  "google_patents_url": "https://patents.google.com/patent/US11401319",
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      "patentNumber": "10364282",
      "countryCode": "US",
      "title": "Training Immune Cells to Fight Specific Cancers",
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  ]
}