{
  "patent_number": "US 11193946",
  "country": "US",
  "title": "Detecting Alzheimer's Risk Early with a Blood Test and Brain Scan",
  "original_title": "Blood biomarker for discerning beta amyloid accumulation in brain",
  "summary": "This patent describes a two-step method to predict early Alzheimer's disease by first checking specific protein levels in a blood sample, and then, if certain markers are low, performing a brain scan to confirm amyloid beta buildup.",
  "what_it_does": "This patent describes a way to detect early signs of Alzheimer's disease in people who don't yet show memory problems and haven't taken certain medications. First, a blood sample is taken to measure the levels of four specific biomarkers: Acetylcholinesterase (AChE), plasma amyloid beta, Lectin galactoside-binding soluble3 binding protein (LGALS3BP), and ACE (Angiotensin I converting enzyme) (Claim 1). If the levels of LGALS3BP, ACE, and AChE are lower than what's typically found in healthy people without brain amyloid, then a special brain scan called a PET test using Pittsburgh compound B (PIB) is performed (Claim 1). This two-step process helps identify individuals who might be accumulating amyloid beta in their brain, a key sign of Alzheimer's, before symptoms appear. For example, if a person with normal memory has low levels of these three blood proteins, the patent suggests they should get a PIB-PET scan to check for amyloid plaques.",
  "what_it_does_not_cover": [
    "Does not cover methods for subjects already diagnosed with cognitive impairment or Alzheimer's dementia.",
    "Does not cover subjects who are currently being treated with an Acetylcholinesterase (AchE) inhibitor.",
    "Does not cover diagnostic methods that rely solely on a PET scan without the initial blood biomarker screening step.",
    "Does not cover methods that use a different set of blood biomarkers, or fewer than the four specified (AchE, plasma amyloid beta, LGALS3BP, ACE) in the initial screening.",
    "Does not cover methods where the decision to perform a PET test is not based on decreased levels of LGALS3BP, ACE, and AChE.",
    "Does not cover methods that use a brain imaging technique other than a PIB-PET test for confirmation."
  ],
  "filed": "2018-03-22",
  "granted": "2021-12-07",
  "expires": "2038-03-22",
  "status": "active",
  "holder": "Seoul National University R&DB Foundation",
  "holder_url": "https://patentbrief.org/company/seoul-national-university-rdb-foundation",
  "inventors": [
    {
      "name": "Sun-Ho HAN",
      "url": "https://patentbrief.org/inventor/sun-ho-han"
    },
    {
      "name": "Inhee Mook",
      "url": "https://patentbrief.org/inventor/inhee-mook"
    },
    {
      "name": "Jong-chan PARK",
      "url": "https://patentbrief.org/inventor/jong-chan-park"
    }
  ],
  "times_cited": 0,
  "tags": [
    "biotech",
    "pharmaceutical",
    "diagnostics",
    "healthcare",
    "medical_devices"
  ],
  "abstract": "Provided concerns a blood biomarker for discerning the cerebral deposition of amyloid beta, which is a causative material of Alzheimer's dementia. A marker according to the subject matter can conveniently and rapidly predictive of cerebral amyloid beta accumulation by use of a blood and can be effectively used in diagnosing relevant diseases including mild cognitive impairment at a preclinical level.",
  "url": "https://patentbrief.org/patent/us/11193946/blood-biomarker-for-discerning-beta-amyloid-accumulation-in-brain",
  "markdown_url": "https://patentbrief.org/patent/us/11193946/blood-biomarker-for-discerning-beta-amyloid-accumulation-in-brain/md",
  "google_patents_url": "https://patents.google.com/patent/US11193946",
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}