{
  "patent_number": "US 10914745",
  "country": "US",
  "title": "Using Blood Markers to Diagnose Stroke and Tell Its Type",
  "original_title": "Biomarker-based methods for aiding the diagnosis of stroke",
  "summary": "This patent describes a two-step method for diagnosing a stroke and then determining if it's an ischemic stroke or a transient ischemic attack (TIA) by measuring specific protein levels in a patient's blood.",
  "what_it_does": "The patent outlines a method for diagnosing a stroke by first measuring the concentration of at least two specific biomarkers in a blood sample. These biomarkers must include at least one from a group like ICAM-1, L-selectin, P-selectin, or VCAM-1, combined with another from a broader list including IL-6, sTNFR1, D-dimer, and CRP. The measured levels are then compared to normal control values. If a stroke is diagnosed, a second method is used to tell if it's an ischemic stroke or a 'mini-stroke' (TIA). This second step involves measuring VCAM-1 and at least one other biomarker from h-FABP, IL-6, or CRP, and comparing those levels to control values from TIA patients. For example, a doctor could take a blood sample, test for elevated ICAM-1 and D-dimer to initially diagnose a stroke, and then, if positive, test for VCAM-1 and h-FABP to differentiate it from a TIA.",
  "what_it_does_not_cover": [
    "Does not cover diagnosing stroke using only a single biomarker; at least two are required by claim 1.",
    "Does not cover methods that do not include at least one biomarker from the specific group of ICAM-1, L-selectin, P-selectin, or VCAM-1 in the initial diagnosis.",
    "Does not cover methods that differentiate stroke types without measuring VCAM-1 in the second step.",
    "Does not cover diagnosing stroke using imaging techniques like MRI or CT scans, as it focuses on *in vitro* (blood sample) biomarker analysis.",
    "Does not cover diagnosing other neurological conditions that might present with similar symptoms but are not strokes or TIAs."
  ],
  "filed": "2017-03-13",
  "granted": "2021-02-09",
  "expires": "2037-03-13",
  "status": "active",
  "holder": "Randox Laboratories",
  "holder_url": "https://patentbrief.org/company/randox-laboratories",
  "inventors": [
    {
      "name": "John LaMont",
      "url": "https://patentbrief.org/inventor/john-lamont"
    },
    {
      "name": "Peter Fitzgerald",
      "url": "https://patentbrief.org/inventor/peter-fitzgerald"
    },
    {
      "name": "Ivan McConnell",
      "url": "https://patentbrief.org/inventor/ivan-mcconnell"
    }
  ],
  "times_cited": 0,
  "tags": [
    "biotech",
    "pharmaceutical",
    "medical_devices",
    "diagnostics"
  ],
  "abstract": "The present invention provides biomarker-based methods for diagnosing stroke in a patient suspected of having suffered a stroke, and also for discriminating between ischemic stroke and transient ischemic attack. Substrates comprising probes for specific combinations of biomarkers useful in the methods of the invention are also described.",
  "url": "https://patentbrief.org/patent/us/10914745/biomarker-based-methods-for-aiding-the-diagnosis-of-stroke",
  "markdown_url": "https://patentbrief.org/patent/us/10914745/biomarker-based-methods-for-aiding-the-diagnosis-of-stroke/md",
  "google_patents_url": "https://patents.google.com/patent/US10914745",
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