{
  "patent_number": "US 10702600",
  "country": "US",
  "title": "How Moderna's mRNA Vaccine Technology Targets Betacoronaviruses",
  "original_title": "Betacoronavirus mRNA vaccine",
  "summary": "A patent describing a specific mRNA vaccine design that uses lipid nanoparticles to deliver genetic instructions for building parts of a betacoronavirus to trigger an immune response.",
  "what_it_does": "The patent claims a vaccine composition that uses messenger RNA (mRNA) to teach the body how to produce a betacoronavirus spike (S) protein. This mRNA is protected and transported into cells using a lipid nanoparticle, which is a tiny fat-based bubble. The specific design includes chemical modifications to the mRNA, such as 1-methylpseudouridine, to help the body accept the genetic instructions without triggering an unwanted inflammatory reaction. The lipid nanoparticle itself is a precise mixture of an ionizable cationic lipid, a neutral lipid like DSPC, cholesterol, and a PEG-modified lipid.",
  "what_it_does_not_cover": [
    "Does not cover vaccines using traditional weakened or inactivated viruses.",
    "Does not cover mRNA sequences that encode proteins unrelated to betacoronavirus S proteins.",
    "Does not cover delivery methods other than the specific lipid nanoparticle formulations described.",
    "Does not cover the use of unmodified (non-chemically modified) mRNA."
  ],
  "filed": "2020-02-28",
  "granted": "2020-07-07",
  "expires": "2040-02-28",
  "status": "active",
  "holder": "ModernaTx Inc",
  "holder_url": "https://patentbrief.org/company/modernatx-inc",
  "inventors": [
    {
      "name": "Giuseppe Ciaramella",
      "url": "https://patentbrief.org/inventor/giuseppe-ciaramella"
    },
    {
      "name": "Sunny Himansu",
      "url": "https://patentbrief.org/inventor/sunny-himansu"
    }
  ],
  "times_cited": 46,
  "tags": [
    "biotech",
    "pharmaceutical"
  ],
  "abstract": "The disclosure relates to respiratory virus ribonucleic acid (RNA) vaccines and combination vaccines, as well as methods of using the vaccines and compositions comprising the vaccines.",
  "url": "https://patentbrief.org/patent/us/10702600/betacoronavirus-mrna-vaccine",
  "markdown_url": "https://patentbrief.org/patent/us/10702600/betacoronavirus-mrna-vaccine/md",
  "google_patents_url": "https://patents.google.com/patent/US10702600",
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}