{
  "patent_number": "US 10525078",
  "country": "US",
  "title": "How to Make Stable Solid Dialysis Powder with Less Odor",
  "original_title": "Solid dialysis A agent containing alkali metal diacetate, and two-part type low-acetate dialysis agent using same",
  "summary": "A specialized solid powder mixture used to create dialysis fluid that stays stable, smells less like vinegar, and keeps acetate levels within a precise, safe range.",
  "what_it_does": "This patent describes a solid powder (Dialysis Agent A) that, when mixed with water and a separate bicarbonate component, creates a medical fluid for kidney dialysis. The key innovation is using an alkali metal diacetate—a specific chemical compound formed by combining acetic acid and an acetate salt—to manage the acidity of the mixture. By keeping the moisture content extremely low (1.1% or less) and using this specific diacetate ratio, the powder remains stable during storage and produces significantly less of the sharp, vinegary smell typically associated with acetic acid in dialysis solutions. It is designed to result in a final fluid with a specific, controlled concentration of acetate ions between 2 and 6 mEq/L.",
  "what_it_does_not_cover": [
    "Does not cover liquid dialysis concentrates that are already dissolved in water.",
    "Does not cover dialysis agents that use different buffering systems not based on acetic acid and acetate salt.",
    "Does not cover formulations where the moisture content exceeds 1.1% by weight.",
    "Does not cover dialysis fluids that require acetate ion concentrations outside the 2 to 6 mEq/L range."
  ],
  "filed": "2014-10-02",
  "granted": "2020-01-07",
  "expires": null,
  "status": "active",
  "holder": "Tomita Pharmaceutical Co Ltd",
  "holder_url": "https://patentbrief.org/company/tomita-pharmaceutical-co-ltd",
  "inventors": [
    {
      "name": "Junya Kikuishi",
      "url": "https://patentbrief.org/inventor/junya-kikuishi"
    },
    {
      "name": "Yusuke Yoshimoto",
      "url": "https://patentbrief.org/inventor/yusuke-yoshimoto"
    },
    {
      "name": "Hiroshi Noguchi",
      "url": "https://patentbrief.org/inventor/hiroshi-noguchi"
    },
    {
      "name": "Michiko MYOSE",
      "url": "https://patentbrief.org/inventor/michiko-myose"
    },
    {
      "name": "Hideyuki Aoyama",
      "url": "https://patentbrief.org/inventor/hideyuki-aoyama"
    },
    {
      "name": "Mina Hashimoto",
      "url": "https://patentbrief.org/inventor/mina-hashimoto"
    }
  ],
  "times_cited": 0,
  "tags": [
    "biotech",
    "mechanical",
    "materials"
  ],
  "abstract": "A solid dialysis A agent is provided, which is to be used in preparing a bicarbonate dialysis fluid, wherein: the solid dialysis A agent contains glucose, acetic acid and an acetate salt; at least a part of a mixture of the acetic acid with the acetate salt is an alkali metal diacetate; and the acetic acid/acetate salt molar ratio is adjusted to 1/0.5 to 1/2. This solid dialysis A agent makes it possible to prepare a bicarbonate dialysis fluid which has a total acetate ion concentration of 2 to less than 6 mEq/L. Further, the dialysis A agent exhibits excellent stability of ingredients and a reduced acetic acid odor.",
  "url": "https://patentbrief.org/patent/us/10525078/trikafta-elexacaftor-tezacaftor-ivacaftor",
  "markdown_url": "https://patentbrief.org/patent/us/10525078/trikafta-elexacaftor-tezacaftor-ivacaftor/md",
  "google_patents_url": "https://patents.google.com/patent/US10525078",
  "relatedPatents": []
}