{
  "patent_number": "US 10479827",
  "country": "US",
  "title": "An Antibody That Detects Specific Sugar-Protein Combinations for Diagnostics",
  "original_title": "Monoclonal antibody reacting with glycopeptide, and use thereof",
  "summary": "This patent describes a unique antibody designed to precisely recognize a specific sugar-protein structure, particularly a 'fucosylated glycopeptide' found on certain proteins like alpha-fetoprotein (AFP), which is useful for medical tests.",
  "what_it_does": "This patent claims a special type of antibody, called a monoclonal antibody, that can find and stick to a very specific target. The target is a 'glycopeptide' (a protein with a sugar attached) that has a 'core fucose moiety' (a specific sugar part) and a particular sequence of amino acids near where the sugar is attached. Crucially, the antibody described in claim 1 and 11 is defined by its unique 'complementarity-determining regions' (CDRs) and reacts with a glycopeptide of formula (1) but not with similar glycopeptides of formulas (2), (3), or (4). For example, it reacts with fucosylated alpha-fetoprotein (AFP), even after the protein has been treated with chemicals like SDS and DTT, which can change its shape, as described in claims 4 and 5.",
  "what_it_does_not_cover": [
    "Does not cover antibodies that react with glycopeptides of formula (2), (3), or (4) as defined by SEQ ID NOs: 14, 15, and 16 in the patent.",
    "Does not cover antibodies that react with alpha-fetoprotein (AFP) that is not fucosylated, even if pretreated with SDS and DTT, as specified in claim 6.",
    "Does not cover antibodies that do not have the specific amino acid sequences for the heavy and light chain CDRs as listed in SEQ ID NOs: 1-6 or 7-12.",
    "Does not cover antibodies that recognize only the amino acid part of the glycopeptide without the core fucose moiety being part of the epitope."
  ],
  "filed": "2017-05-30",
  "granted": "2019-11-19",
  "expires": "2037-05-30",
  "status": "active",
  "holder": "Sysmex",
  "holder_url": "https://patentbrief.org/company/sysmex",
  "inventors": [
    {
      "name": "Koji FUKAGAWA",
      "url": "https://patentbrief.org/inventor/koji-fukagawa"
    },
    {
      "name": "Yukiko HIGA",
      "url": "https://patentbrief.org/inventor/yukiko-higa"
    },
    {
      "name": "Yukiko Kataoka",
      "url": "https://patentbrief.org/inventor/yukiko-kataoka"
    },
    {
      "name": "Tsuyoshi Nomura",
      "url": "https://patentbrief.org/inventor/tsuyoshi-nomura"
    },
    {
      "name": "Yuriko EGASHIRA",
      "url": "https://patentbrief.org/inventor/yuriko-egashira"
    }
  ],
  "times_cited": 0,
  "tags": [
    "biotech",
    "pharmaceutical",
    "diagnostics",
    "medical_devices"
  ],
  "abstract": "Disclosed is a monoclonal antibody reacting with a glycopeptide, wherein the glycopeptide contains a core fucose moiety and at least 4 contiguous amino acid residues that are located on the C-terminal side of a glycosylated asparagine moiety, and both of the core fucose moiety in the glycopeptide and an amino acid residue that is located apart by at least three amino acid residues from the C-terminal of the glycosylated asparagine moiety in the glycopeptide are epitopes for the antibody.",
  "url": "https://patentbrief.org/patent/us/10479827/monoclonal-antibody-reacting-with-glycopeptide-and-use-thereof",
  "markdown_url": "https://patentbrief.org/patent/us/10479827/monoclonal-antibody-reacting-with-glycopeptide-and-use-thereof/md",
  "google_patents_url": "https://patents.google.com/patent/US10479827",
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}