{
  "patent_number": "US 10472419",
  "country": "US",
  "title": "How Novartis Engineered Antibodies to Block the TIM-3 Immune Checkpoint",
  "original_title": "Antibody molecules to TIM-3 and uses thereof",
  "summary": "A patent describing specific genetic blueprints for antibodies designed to bind to and inhibit the TIM-3 protein, a key target in cancer and immune system research.",
  "what_it_does": "This patent defines the specific genetic sequences (nucleic acid molecules) required to produce antibodies that target TIM-3, a protein found on the surface of immune cells. By binding to TIM-3, these antibodies act as a molecular key that can potentially unlock the immune system's ability to fight tumors. The patent lists precise amino acid sequences for the 'variable regions' of the antibodies—the parts that actually grab onto the target. These sequences are organized into specific combinations (CDR sets) that ensure the antibody binds to TIM-3 with high specificity.",
  "what_it_does_not_cover": [
    "Does not cover any antibody that binds to TIM-3 using different amino acid sequences than those explicitly listed in the claims.",
    "Does not cover the general concept of targeting TIM-3, only the specific antibody structures defined by the provided SEQ ID sequences.",
    "Does not cover therapeutic methods or clinical protocols for treating patients, only the genetic material for creating the antibodies themselves."
  ],
  "filed": "2017-02-14",
  "granted": "2019-11-12",
  "expires": null,
  "status": "active",
  "holder": "Novartis AG",
  "holder_url": "https://patentbrief.org/company/novartis-ag",
  "inventors": [
    {
      "name": "Rosemarie H. DeKruyff",
      "url": "https://patentbrief.org/inventor/rosemarie-h-dekruyff"
    },
    {
      "name": "Barbara Brannetti",
      "url": "https://patentbrief.org/inventor/barbara-brannetti"
    },
    {
      "name": "Jennifer Marie Mataraza",
      "url": "https://patentbrief.org/inventor/jennifer-marie-mataraza"
    },
    {
      "name": "Maximiliano Vasquez",
      "url": "https://patentbrief.org/inventor/maximiliano-vasquez"
    },
    {
      "name": "Gordon James Freeman",
      "url": "https://patentbrief.org/inventor/gordon-james-freeman"
    },
    {
      "name": "Walter A. Blattler",
      "url": "https://patentbrief.org/inventor/walter-a-blattler"
    },
    {
      "name": "Daniel J. Hicklin",
      "url": "https://patentbrief.org/inventor/daniel-j-hicklin"
    },
    {
      "name": "Thomas Huber",
      "url": "https://patentbrief.org/inventor/thomas-huber"
    },
    {
      "name": "Thomas Pietzonka",
      "url": "https://patentbrief.org/inventor/thomas-pietzonka"
    },
    {
      "name": "Catherine Anne Sabatos-Peyton",
      "url": "https://patentbrief.org/inventor/catherine-anne-sabatos-peyton"
    },
    {
      "name": "Alan S. Harris",
      "url": "https://patentbrief.org/inventor/alan-s-harris"
    },
    {
      "name": "Tiancen Hu",
      "url": "https://patentbrief.org/inventor/tiancen-hu"
    },
    {
      "name": "John A. Taraszka",
      "url": "https://patentbrief.org/inventor/john-a-taraszka"
    },
    {
      "name": "Dale T. Umetsu",
      "url": "https://patentbrief.org/inventor/dale-t-umetsu"
    },
    {
      "name": "Fangmin Xu",
      "url": "https://patentbrief.org/inventor/fangmin-xu"
    }
  ],
  "times_cited": 10,
  "tags": [
    "biotech",
    "pharmaceutical"
  ],
  "abstract": "Antibody molecules that specifically bind to TIM-3 are disclosed. The anti-TIM-3 antibody molecules can be used to treat, prevent and/or diagnose immune, cancerous, or infectious conditions and/or disorders.",
  "url": "https://patentbrief.org/patent/us/10472419/keytruda-pembrolizumab",
  "markdown_url": "https://patentbrief.org/patent/us/10472419/keytruda-pembrolizumab/md",
  "google_patents_url": "https://patents.google.com/patent/US10472419",
  "relatedPatents": []
}