{
  "patent_number": "US 10400035",
  "country": "US",
  "title": "Using Antibodies to Protect Transplanted Organs from Damage",
  "original_title": "Methods of protecting a solid organ transplant tissue with angiopoietin-2 antibodies",
  "summary": "A medical method for preserving transplanted organs by using specific antibodies to block a protein that causes inflammation and blood vessel leakage.",
  "what_it_does": "This patent describes a way to keep a donated organ healthy after it is moved into a patient's body. It focuses on using a specific type of antibody that targets a protein called Angiopoietin-2 (Ang-2). When an organ is transplanted, it often suffers from ischemia, which is a lack of blood flow, followed by damage when blood flow returns. The method involves bathing or perfusing the organ with these antibodies to stop Ang-2 from making blood vessels leaky and causing harmful inflammation.",
  "what_it_does_not_cover": [
    "Does not cover antibodies that bind to Angiopoietin-1 (Ang-1).",
    "Does not cover treatments that do not use the specific variable heavy and light chain sequences defined in the patent.",
    "Does not cover systemic administration of the drug to the patient's entire body, only the perfusion of the allograft itself."
  ],
  "filed": "2017-11-22",
  "granted": "2019-09-03",
  "expires": null,
  "status": "active",
  "holder": "University of Helsinki",
  "holder_url": "https://patentbrief.org/company/university-of-helsinki",
  "inventors": [
    {
      "name": "Jane Connor",
      "url": "https://patentbrief.org/inventor/jane-connor"
    },
    {
      "name": "Karl Lemstrom",
      "url": "https://patentbrief.org/inventor/karl-lemstrom"
    },
    {
      "name": "Kari Alitalo",
      "url": "https://patentbrief.org/inventor/kari-alitalo"
    },
    {
      "name": "Ronald Herbst",
      "url": "https://patentbrief.org/inventor/ronald-herbst"
    },
    {
      "name": "Simo Syrjala",
      "url": "https://patentbrief.org/inventor/simo-syrjala"
    },
    {
      "name": "Ching Ching Leow",
      "url": "https://patentbrief.org/inventor/ching-ching-leow"
    }
  ],
  "times_cited": 0,
  "tags": [
    "biotech",
    "pharmaceutical"
  ],
  "abstract": "The disclosure is directed to methods and uses of antibodies or antigen-binding fragments thereof against Angiopoietin-2 (Ang-2). Specifically, the disclosure is direct to the use of anti-Ang2 antibodies or antigen-binding fragments thereof for treating ischemia. The methods disclosed are useful for reducing microvascular permeability, increasing microvascular perfusion, reducing inflammation in a tissue, and treating or ameliorating diseases associated with ischemia and/or reperfusion injury. The disclosed methods are also useful for protecting solid organ transplant tissue and treating or preventing chronic tissue transplant rejection.",
  "url": "https://patentbrief.org/patent/us/10400035/ocrevus-ocrelizumab",
  "markdown_url": "https://patentbrief.org/patent/us/10400035/ocrevus-ocrelizumab/md",
  "google_patents_url": "https://patents.google.com/patent/US10400035",
  "relatedPatents": []
}