{
  "patent_number": "US 10377797",
  "country": "US",
  "title": "Training Immune Cells to Fight Cancer Using Specific Markers",
  "original_title": "Cell epitopes and combination of cell epitopes for use in the immunotherapy of myeloma and other cancers",
  "summary": "This patent describes a method to create a powerful immune response against cancer by taking a patient's own T cells, teaching them to recognize specific cancer markers outside the body, and then putting them back to kill cancer cells.",
  "what_it_does": "The patent describes a method to fight cancer by using specially trained T cells. First, T cells are taken, often from the patient themselves (Claim 2). These T cells are then \"taught\" outside the body (Claim 11) to recognize specific small protein pieces, called peptides (SEQ ID NO: 1-5, 7-10), that are found on cancer cells. This teaching happens by exposing the T cells to these peptides presented on special \"antigen-presenting cells\" (Claim 1) using a human class I MHC molecule. This process activates the T cells. Once activated, these T cells are multiplied (Claim 5) and then given back to the patient (Claim 1) to seek out and destroy cancer cells that display these specific peptides. For example, a patient with lung cancer could have their T cells trained to recognize a lung cancer-specific peptide and then re-infused to attack the tumor.",
  "what_it_does_not_cover": [
    "Does not cover methods where T cells are activated inside the patient's body without ex vivo manipulation.",
    "Does not cover immunotherapies that do not involve administering activated T cells (e.g., traditional chemotherapy or radiation).",
    "Does not cover T cell therapies that target cancer cells using different recognition mechanisms, such as CAR T cells which recognize whole proteins, not specific MHC-presented peptides.",
    "Does not cover methods using peptides other than those specifically listed (SEQ ID NO: 1-5, 7-10) for T cell activation.",
    "Does not cover methods where the T cells are not activated by a peptide loaded onto a human class I MHC molecule on an antigen-presenting cell."
  ],
  "filed": "2018-11-20",
  "granted": "2019-08-13",
  "expires": "2038-11-20",
  "status": "active",
  "holder": "Immatics Biotechnologies",
  "holder_url": "https://patentbrief.org/company/immatics-biotechnologies",
  "inventors": [
    {
      "name": "Daniel Johannes Kowalewski",
      "url": "https://patentbrief.org/inventor/daniel-johannes-kowalewski"
    },
    {
      "name": "Hans-Georg Rammensee",
      "url": "https://patentbrief.org/inventor/hans-georg-rammensee"
    },
    {
      "name": "Juliane STICKEL",
      "url": "https://patentbrief.org/inventor/juliane-stickel"
    },
    {
      "name": "Simon Walz",
      "url": "https://patentbrief.org/inventor/simon-walz"
    },
    {
      "name": "Stefan Stevanovic",
      "url": "https://patentbrief.org/inventor/stefan-stevanovic"
    }
  ],
  "times_cited": 5,
  "tags": [
    "biotech",
    "pharmaceutical",
    "oncology"
  ],
  "abstract": "The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer, in particular myeloma. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.",
  "url": "https://patentbrief.org/patent/us/10377797/cell-epitopes-and-combination-of-cell-epitopes-for-use-in-the-immunotherapy-of-m",
  "markdown_url": "https://patentbrief.org/patent/us/10377797/cell-epitopes-and-combination-of-cell-epitopes-for-use-in-the-immunotherapy-of-m/md",
  "google_patents_url": "https://patents.google.com/patent/US10377797",
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}