{
  "patent_number": "US 10364282",
  "country": "US",
  "title": "Training Immune Cells to Fight Specific Cancers",
  "original_title": "Peptides and combination of peptides for use in immunotherapy against esophageal cancer and other cancers",
  "summary": "This patent describes a method to treat specific cancers like esophageal or lung cancer by creating specialized immune cells in the lab and giving them to patients to kill cancer cells that display a particular protein fragment.",
  "what_it_does": "The patent claims a method for treating cancers that produce too much of a protein called KRT5. It involves taking a patient's own immune cells, specifically T cells, or T cells from a healthy donor (claim 3), and training them in a lab (in vitro) to recognize a specific part of the KRT5 protein (SEQ ID NO: 2) when it's presented by another cell (an antigen presenting cell) on an MHC class I molecule (claim 1). These trained T cells, called cytotoxic T cells, are then activated and expanded in number (claim 5) before being given back to the patient. Once inside the patient, these activated T cells target and kill cancer cells overexpressing KRT5, such as those found in esophageal cancer (claim 16) or lung cancer (claim 17). For example, a patient with esophageal cancer could receive a dose of their own T cells, which were previously taught in a lab to find and destroy cells showing the KRT5 protein fragment.",
  "what_it_does_not_cover": [
    "Does not cover immunotherapy methods that target cancer cells without specifically relying on the KRT5 polypeptide (SEQ ID NO: 2).",
    "Does not cover treatments for cancers that do not overexpress the KRT5 polypeptide.",
    "Does not cover T-cell therapies where the T cells are not activated in vitro by an antigen-presenting cell presenting the specific SEQ ID NO: 2 peptide with an MHC class I molecule.",
    "Does not cover treatments for cancers outside the specified list, which includes esophageal, lung, urinary bladder, head and neck, and gastric cancers.",
    "Does not cover immune therapies that use antibodies or other binding molecules to target the KRT5 peptide directly without involving activated T cells."
  ],
  "filed": "2019-02-21",
  "granted": "2019-07-30",
  "expires": "2039-02-21",
  "status": "active",
  "holder": "Immatics Biotechnologies",
  "holder_url": "https://patentbrief.org/company/immatics-biotechnologies",
  "inventors": [
    {
      "name": "Oliver Schoor",
      "url": "https://patentbrief.org/inventor/oliver-schoor"
    },
    {
      "name": "Colette SONG",
      "url": "https://patentbrief.org/inventor/colette-song"
    },
    {
      "name": "Harpreet Singh",
      "url": "https://patentbrief.org/inventor/harpreet-singh"
    },
    {
      "name": "Andrea MAHR",
      "url": "https://patentbrief.org/inventor/andrea-mahr"
    },
    {
      "name": "Toni Weinschenk",
      "url": "https://patentbrief.org/inventor/toni-weinschenk"
    },
    {
      "name": "Jens FRITSCHE",
      "url": "https://patentbrief.org/inventor/jens-fritsche"
    }
  ],
  "times_cited": 2,
  "tags": [
    "biotech",
    "pharmaceutical",
    "immunotherapy",
    "oncology",
    "cell_therapy"
  ],
  "abstract": "The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.",
  "url": "https://patentbrief.org/patent/us/10364282/peptides-and-combination-of-peptides-for-use-in-immunotherapy-against-esophageal",
  "markdown_url": "https://patentbrief.org/patent/us/10364282/peptides-and-combination-of-peptides-for-use-in-immunotherapy-against-esophageal/md",
  "google_patents_url": "https://patents.google.com/patent/US10364282",
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}