{
  "patent_number": "US 10357559",
  "country": "US",
  "title": "How to Make Anthrax Vaccines That Survive Freezing",
  "original_title": "Temperature stable vaccine formulations",
  "summary": "A method for protecting sensitive anthrax vaccines from damage during freezing and thawing by using specific sugars and additives during the drying process.",
  "what_it_does": "This patent describes a way to stabilize anthrax vaccines so they do not lose their effectiveness when frozen or dried. The process involves taking an anthrax antigen attached to an aluminum adjuvant and swapping out the original liquid for a new mixture containing high concentrations of non-reducing sugars like trehalose or sucrose. By removing the original liquid through centrifugation or filtration and replacing it with this sugar-rich solution, the vaccine can be lyophilized (freeze-dried) without the proteins falling apart. This ensures the vaccine remains potent even after being stored in harsh conditions.",
  "what_it_does_not_cover": [
    "Does not cover vaccines that do not use aluminum-based adjuvants.",
    "Does not cover liquid-only vaccines that are not intended for lyophilization.",
    "Does not cover the use of reducing sugars like glucose or fructose for stabilization.",
    "Does not cover methods that do not involve the specific step of exchanging the liquid component."
  ],
  "filed": "2014-12-23",
  "granted": "2019-07-23",
  "expires": null,
  "status": "active",
  "holder": "Emergent Product Development Gaithersburg Inc",
  "holder_url": "https://patentbrief.org/company/emergent-product-development-gaithersburg-inc",
  "inventors": [
    {
      "name": "Richard William Welch",
      "url": "https://patentbrief.org/inventor/richard-william-welch"
    },
    {
      "name": "Aaron Paul Miles",
      "url": "https://patentbrief.org/inventor/aaron-paul-miles"
    },
    {
      "name": "Christian Fernando Ruiz",
      "url": "https://patentbrief.org/inventor/christian-fernando-ruiz"
    },
    {
      "name": "Jee Look",
      "url": "https://patentbrief.org/inventor/jee-look"
    }
  ],
  "times_cited": 0,
  "tags": [
    "biotech",
    "pharmaceutical"
  ],
  "abstract": "Vaccine antigen formulations that are stable after undergoing freeze and thaw conditions and methods of preparing the formulations are provided. Methods of using the formulations to prepare vaccine are also provided. Vaccines comprising the formulations are useful, for example, to protect against, inhibit or alleviate a disease or infection, such as related to anthrax infection.",
  "url": "https://patentbrief.org/patent/us/10357559/luxturna-voretigene-neparvovec",
  "markdown_url": "https://patentbrief.org/patent/us/10357559/luxturna-voretigene-neparvovec/md",
  "google_patents_url": "https://patents.google.com/patent/US10357559",
  "relatedPatents": []
}