{
  "patent_number": "US 10184000",
  "country": "US",
  "title": "How to Engineer Antibodies to Better Target and Destroy Disease",
  "original_title": "Optimized Fc variants and methods for their generation",
  "summary": "This patent describes a way to modify the tail end of an antibody so it binds more strongly to immune cells, helping the body fight off infections or cancer more effectively.",
  "what_it_does": "The patent claims specific modifications to the Fc region of an antibody, which is the 'tail' part that tells the immune system what to do. By swapping specific amino acids at positions 239 and 332—specifically using aspartic acid (D) or glutamic acid (E)—the antibody is engineered to bind more tightly to a receptor called FcγRIIIa. This receptor is found on natural killer cells and other immune cells. When the antibody binds more tightly to these cells, it triggers a stronger immune response, making the antibody much better at flagging and destroying target cells like cancer cells.",
  "what_it_does_not_cover": [
    "Does not cover antibodies that do not contain the specific 239 and 332 amino acid substitutions.",
    "Does not cover naturally occurring, non-engineered Fc regions.",
    "Does not cover methods of treating patients, only the genetic material and production methods for the modified antibodies.",
    "Does not cover Fc variants that use different amino acid positions for binding enhancement."
  ],
  "filed": "2016-05-27",
  "granted": "2019-01-22",
  "expires": null,
  "status": "active",
  "holder": "Xencor Inc",
  "holder_url": "https://patentbrief.org/company/xencor-inc",
  "inventors": [
    {
      "name": "Sher Bahadur Karki",
      "url": "https://patentbrief.org/inventor/sher-bahadur-karki"
    },
    {
      "name": "Arthur J. Chirino",
      "url": "https://patentbrief.org/inventor/arthur-j-chirino"
    },
    {
      "name": "Stephen K. Doberstein",
      "url": "https://patentbrief.org/inventor/stephen-k-doberstein"
    },
    {
      "name": "John Desjarlais",
      "url": "https://patentbrief.org/inventor/john-desjarlais"
    },
    {
      "name": "Omid Vafa",
      "url": "https://patentbrief.org/inventor/omid-vafa"
    },
    {
      "name": "Gregory Alan Lazar",
      "url": "https://patentbrief.org/inventor/gregory-alan-lazar"
    },
    {
      "name": "Wei Dang",
      "url": "https://patentbrief.org/inventor/wei-dang"
    },
    {
      "name": "Robert J. Hayes",
      "url": "https://patentbrief.org/inventor/robert-j-hayes"
    }
  ],
  "times_cited": 12,
  "tags": [
    "biotech",
    "pharmaceutical"
  ],
  "abstract": "The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.",
  "url": "https://patentbrief.org/patent/us/10184000/libtayo-cemiplimab",
  "markdown_url": "https://patentbrief.org/patent/us/10184000/libtayo-cemiplimab/md",
  "google_patents_url": "https://patents.google.com/patent/US10184000",
  "relatedPatents": []
}