{
  "patent_number": "US 10106579",
  "country": "US",
  "title": "How Synthetic Peptides Block Immune System Overreaction",
  "original_title": "Modulation of complement activity",
  "summary": "A patent describing specific synthetic peptides designed to stop the body's immune system from attacking healthy cells by blocking a protein called C5.",
  "what_it_does": "This patent describes a family of synthetic peptides—short chains of amino acids—that act as precision tools to modulate the complement system. The complement system is a part of the immune system that normally helps clear pathogens, but when overactive, it can cause severe inflammation and tissue damage. The claimed peptides include specific structures that use bridging moieties, such as aromatic rings or thioether bonds, to lock the peptide into a stable, cyclic shape. This shape allows the peptide to bind specifically to the C5 protein, preventing it from being cleaved into smaller, active parts that trigger immune attacks. By inhibiting this cleavage, these peptides can be used to treat conditions like paroxysmal nocturnal hemoglobinuria or atypical hemolytic uremic syndrome.",
  "what_it_does_not_cover": [
    "Does not cover naturally occurring peptides found in the human body.",
    "Does not cover general methods of protein synthesis not involving these specific sequences.",
    "Does not cover non-peptide inhibitors of the complement system.",
    "Does not cover treatments for diseases not related to complement system activity."
  ],
  "filed": "2015-06-12",
  "granted": "2018-10-23",
  "expires": null,
  "status": "active",
  "holder": "Ra Pharmaceuticals Inc",
  "holder_url": "https://patentbrief.org/company/ra-pharmaceuticals-inc",
  "inventors": [
    {
      "name": "Alonso Ricardo",
      "url": "https://patentbrief.org/inventor/alonso-ricardo"
    },
    {
      "name": "Daniel Elbaum",
      "url": "https://patentbrief.org/inventor/daniel-elbaum"
    },
    {
      "name": "Robert Paul Hammer",
      "url": "https://patentbrief.org/inventor/robert-paul-hammer"
    },
    {
      "name": "Kelley Cronin Larson",
      "url": "https://patentbrief.org/inventor/kelley-cronin-larson"
    },
    {
      "name": "Douglas A. Treco",
      "url": "https://patentbrief.org/inventor/douglas-a-treco"
    },
    {
      "name": "Sarah Jacqueline Perlmutter",
      "url": "https://patentbrief.org/inventor/sarah-jacqueline-perlmutter"
    },
    {
      "name": "Ping Ye",
      "url": "https://patentbrief.org/inventor/ping-ye"
    },
    {
      "name": "Kathleen Seyb",
      "url": "https://patentbrief.org/inventor/kathleen-seyb"
    },
    {
      "name": "Guo-Qing Tang",
      "url": "https://patentbrief.org/inventor/guo-qing-tang"
    },
    {
      "name": "Ketki Ashok Dhamnaskar",
      "url": "https://patentbrief.org/inventor/ketki-ashok-dhamnaskar"
    },
    {
      "name": "Zhaolin Wang",
      "url": "https://patentbrief.org/inventor/zhaolin-wang"
    },
    {
      "name": "Hong Zheng",
      "url": "https://patentbrief.org/inventor/hong-zheng"
    },
    {
      "name": "Kristopher Josephson",
      "url": "https://patentbrief.org/inventor/kristopher-josephson"
    },
    {
      "name": "Zhong Ma",
      "url": "https://patentbrief.org/inventor/zhong-ma"
    },
    {
      "name": "Michelle Denise Hoarty",
      "url": "https://patentbrief.org/inventor/michelle-denise-hoarty"
    },
    {
      "name": "Nathan Ezekiel Nims",
      "url": "https://patentbrief.org/inventor/nathan-ezekiel-nims"
    }
  ],
  "times_cited": 8,
  "tags": [
    "biotech",
    "pharmaceutical"
  ],
  "abstract": "The present invention provides modulators of complement activity. Also provided are methods of utilizing such modulators as therapeutics.",
  "url": "https://patentbrief.org/patent/us/10106579/orkambi-lumacaftor-ivacaftor",
  "markdown_url": "https://patentbrief.org/patent/us/10106579/orkambi-lumacaftor-ivacaftor/md",
  "google_patents_url": "https://patents.google.com/patent/US10106579",
  "relatedPatents": []
}